Magnetic resonance imaging physics for the study of small vessel disease in humans at ultra-high field

摘要：该项目的总体目标是开发用于血管和灌注成像的7T MRI方法，使用射频工程小组正在开发的多发射射频线圈，用于高分辨率成像人脑。这将通过一系列子项目实现，分别具有以下目标：(1)使用计算机模拟设计优化的pTx脉冲序列；(2)使用定制的软件开发工具在7T MRI扫描仪上实现这些脉冲序列；(3)测试对象（幻影）和健康对象的脉冲序列性能测试；(4)对多个射频线圈进行比较研究，以确定哪个线圈为血管应用提供最高质量的图像；(5)初步临床研究，评估其在小血管病变表征方面的改善。所有子项目将由研究团队中一名合适的博士后成员密切支持。

Studentship strategic priority area: Medical ImagingKeywords: Stroke, MRI, MRA, ASL, parallel-transmitAbstract: The overall aim of the project is to develop 7T MRI methods for vascular and perfusion imaging using multi-transmit RF coils that are being developed by our RF Engineering group for high-resolution imaging the human brain. This will be achieved as a series of sub-projects with the following objectives respectively: (1) the design of optimised pTx pulse sequences using computer simulation; (2) the implementation of these pulse sequences on the 7T MRI scanner using bespoke software development tools; (3) performance testing of the pulse sequences in test objects (phantoms) and healthy subjects; (4) comparison study between multiple RF coils to determine which coil provides the highest quality images for vascular applications; and (5) preliminary clinical study to assess the improvement in characterizing disease in small vessels. All sub-projects will be closely supported by an appropriate post-doctoral member of the research team.