Reliability of Cognitive ERPs in Children and Adults

描述(由申请人提供)：该研究计划的长期目标是为越来越多的证据表明大脑在成年早期继续发育做出贡献。脑电(EEC)测量和神经心理学评估被用来研究儿童和青少年特定脑区成熟与认知和情感过程发展的相互关系。这项研究的结果将被应用于一个模型的开发，该模型将阐明代表个体的刺激-反应机制、特征和状态特征的变量之间的相互关系，以及它们在采用纵向设计的典型发育儿童的定期评估期间观察到的各种ERP测量的相关变化。这项研究的目的是：1)确定事件相关电位的可靠性是否存在发展趋势；2)阐明执行功能，特别是注意力与事件相关电位成分和事件相关电位可靠性的关系。研究设计包括从3个年龄组(8岁、12岁和年轻人)各30名受试者获得多通道脑电记录，同时执行3种事件相关电位范式：新奇听觉古怪(听觉辨别任务)、偶然性负变化(持续注意任务)和错误相关负性(简单视觉辨别任务中的错误监控)。每个参与者将在间隔1-2周的两次访问中完成这些EEG/ERP任务。然后将确定这些企业资源规划范例的主要组成部分的分半信度系数和重测信度系数。然后，将使用标准残差而不是原来的企业资源规划措施重新计算分半和重测。这些新的可靠性系数预计将高于那些不考虑由于波形处理而产生的方差的系数。将评估注意措施与事件相关电位可靠性和事件相关电位成分(即CNV、P3a、P3b和ERN)的关系。与健康相关的影响包括了解儿童和青春期大脑与注意力有关的变化。此外，研究结果有可能为认知事件相关电位和事件相关电位可靠性的个体差异提供丰富的信息。这些信息将是有帮助的，特别是当临床人群(例如，注意力缺陷障碍和学习障碍)被纳入发育性ERP研究时。

DESCRIPTION (provided by applicant): The long-term goals of this program of research are to contribute to the increasing amount of evidence for continued development of the brain into early adulthood. Electroencephalographic (EEC) measures and neuropsychological assessments are being employed to investigate the interrelationships of maturation of specific brain regions and the development of cognitive and emotional processes in children and adolescents. The results obtained from this study will be applied to the development of a model that will elucidate interrelationships of variables representing stimulus-response mechanisms, trait, and state characteristics of an individual and their associated changes in various ERP measurements observed during periodic assessments in typically developing children using a longitudinal design. The goals of the proposed research are to: 1) Determine if developmental trends exist in the reliability of ERPs, and 2) Clarify the relationship of executive functions, specifically attention, to ERPs components and ERP reliability. The research design entails obtaining multiple channel EEC recordings from 30 participants in each of 3 age groups (8-yr olds, 12-yr olds and young adults) while performing 3 ERP paradigms: the novelty auditory oddball (an auditory discrimination task), contingent negative variation (a sustained attention task), and the error-related negativity (error-monitoring in simple visual discrimination task). Each participant will complete these EEG/ERP tasks in each of two visits separated by a 1-2 week period. Split-half and test-retest reliability coefficients will then be determined for the principle components of these ERP paradigms. Split-half and test-retest will then be recomputed using the standardized residuals instead of the original ERP measures. These new reliability coefficients are expected to be higher than those not accounting for variance due to waveform processing. Relationships of attentional measures and ERP reliability and the ERP components (i.e, CNV, P3a, P3b and ERN) will be evaluated. Health related impacts include understanding changes in the brain in relation to attention in childhood and adolescence. In addition, results have the potential of providing a wealth of information regarding individual differences in cognitive ERPs and ERP reliability. This information will be helpful, especially when clinical populations (e.g., attention deficit disorders and learning disabilities) are included in developmental ERP studies.