A Computational Tool for Simulation of Phonosurgical Pr*

描述（由申请人提供）：该项目的长期目标是预测喉发声手术的结果与生理基础的语音模拟。拟议的研究将朝着这个目标，通过发展一个模型的声带姿态。声带姿态是发声控制的一个基本方面，被定义为声带的内收、外展或伸长。由于姿势是基于喉关节力学和软组织变形，连续介质力学的基本理论来制定这个模型。应用连续介质力学的喉姿态需要一个准确的几何和力学描述的各种组织在喉，如声带韧带和喉内肌。此外，由于这些组织中的许多是纤维性的，因此具有不同的作用线，因此需要描绘被动和收缩应力贡献以及纤维方向。目前项目的具体目标是： I.以数学方式表示分化的喉肌束的方向，允许分布在各种软骨上的肌肉力量。 二.根据声带固有肌束的分布情况，建立声带力学的三维有限元模型，预测声带内、外侧化的速度和范围。 三.模拟I型甲状腺成形术的发音外科手术，并预测修复后的声门构型以及修复后声带中的应力分布。 预计姿势模型将对基于手术的语音治疗以及一般和手术后治疗的声带建模产生重大影响。

DESCRIPTION (provided by applicant): The long-term goal of this project is to predict outcomes of laryngeal phonosurgery with physiologically based voice simulation. The proposed research will move towards this goal by developing a model of vocal fold posturing. Vocal fold posturing, a fundamental aspect of phonation control, is defined as adduction, abduction, or elongation of the vocal folds. Because posturing is based on laryngeal joint mechanics and soft tissue deformation, fundamental theories of continuum mechanics are used to formulate this model. The application of continuum mechanics to laryngeal posturing requires an accurate geometric and mechanical description of various tissues in the larynx, such as the vocal ligament and intrinsic laryngeal muscles. Furthermore, because many of these tissues are fibrous and thus have distinct lines of action, a portrayal of passive and contractile stress contributions and fiber direction is needed. The specific aims of the current project are: I. To mathematically represent the orientation of differentiated laryngeal muscle bundles, allowing for distributed muscle forces over various cartilages. II. To create, with the distribution of intrinsic muscle bundles, a three-dimensional finite element model of vocal fold mechanics that can predict both the speed and the range of vocal fold medialization and lateralization. III. To simulate a Type I thyroplasty phonosurgery and predict the resultant glottal configuration as well as the resultant stress distribution in the repaired vocal fold. It is expected that the posturing model will have a significant impact on surgically based voice therapies, as well as on vocal fold modeling in general and post-surgical therapy.