The lexicon of antimicrobial peptides: resistance and mechanisms

了解抗菌素耐药性的出现是全球人类健康面临的关键挑战之一，但它也是影响有效抗菌剂开发的关键生物学现象。因此，该项目与应对战略挑战紧密契合，特别是生物科学促进对健康的综合理解，其中有一个关键目标是能够开发工具和干预措施来应对[...]对抗菌化合物的抗药性。然而，解决抗菌肽的耐药率和机制将回答微生物与多肽相互作用的基本生物学问题，这将有助于推进生物科学发现的前沿。所使用的多肽“宇宙”的全面方面意味着具体地推进围绕理解生命规则的理解。在此过程中，该项目将开发抗菌肽的转化技术和微生物耐药率的检测。最后，通过将这个拥有一系列卫生技术专业知识的监督团队聚集在一起，特别关注抗菌肽(Dobson)、进化机制(Knight)和抗菌素耐药性基因组学(Gifford)，该项目将在合作、伙伴关系和知识交流方面以及在学生自身发展的人员和人才的战略重要性方面建立坚实的基础。

Understanding the emergence of antimicrobial resistance is one of the key challenges for global human health, but it is also a critical biological phenomenon affecting the development of effective antimicrobials. Thus the project fits closely within Tackling strategic challenges, specifically, Bioscience for an Integrated understanding of health where there is a key objective to Enable the development of tools and interventions to tackle [...] resistance to antimicrobial compounds. However, addressing the rates and mechanisms of resistance to antimicrobial peptides will answer fundamental biological questions of microbial interactions with peptides, which will help in Advancing the frontiers of bioscience discovery. The comprehensive aspect of the 'universe' of peptides used means specifically advancing the understanding around Understanding the rules of life. In the process, this project will develop the Transformative technologies of antimicrobial peptides and assays of microbial resistance rates. Finally, by bringing together this supervisory team with expertise in a range of health technologies with a particular focus on antimicrobial peptides (Dobson) along with evolutionary mechanisms (Knight) and the genomics of antimicrobial resistance (Gifford) this project will be Building strong foundations, both in terms of the Collaboration, partnership and knowledge exchange involved and in terms of the strategic importance of the People and talent it will develop in the student themselves.