Understanding how macrophages respond to damage-derived inflammatory signals.

该项目将促进一种创造性和好奇心驱动的方法来解决生物学中的一个基本问题-翻译后修饰如何控制对炎症危险信号的反应以维持体内平衡？由于P2 X7 R在巨噬细胞以外的细胞中表达，即内皮细胞和上皮细胞、T细胞或先天性类巨噬细胞，理解控制P2 X7 R信号传导的机制将利用跨多个学科的知识、工具和专业知识，如信号转导、受体运输和免疫和炎症，符合BBSRC的“理解生命规则”的职责。此外，该项目也符合“生物科学对健康的综合理解”，因为该项目将带来对在压力和生物或环境挑战下保持健康和健康所需的细胞机制的新理解。该项目将提供专业知识深度的多学科培训，并为博士生提供广泛的专业和可转移技能。

This project will promote a creative and curiosity-driven approach to address a fundamental question in biology How posttranslational modifications control responses to the inflammatory danger signals to maintain homeostasis? As P2X7Rs are expressed in cells other than macrophages i.e. endothelial and epithelial cells, T cells or Innate Lymphoid cells understanding the mechanism that control P2X7R signalling will leverage knowledge, tools and expertise across multiple disciplines such as Signal transduction, Receptor trafficking and Immunity and Inflammation fitting with the "Understanding the rules of life" remit of BBSRC. In addition, this project also fits the "Bioscience for an integrated understanding of health" as this project will bring a new understanding on cellular mechanisms required to maintain health and wellness under stress and biological or environmental challenges. This project will provide a multidisciplinary training for depth of expertise as well as equipping the PhD student with a breadth of professional and transferable skills.