The Chernobyl Tissue Bank

描述(由申请人提供)：本项目的主要目标是为正在进行的和未来研究化学分子事故的健康后果提供研究资源(化学分子组织库：CTB)。它寻求通过向世界各地的研究人员提供从记录良好的病理标本中提取的多等份RNA和DNA来最大化从小块肿瘤中获得的信息量，并为未来几代科学家保存这些宝贵的材料。它的存在是为了促进对有限生物资源的合作研究，而不是竞争研究。反恐委员会确保向患者提供尽可能好的诊断服务，确保每个生物样本都获得适当的伦理同意，确保样本得到适当的记录和采样，并确保生物材料可用于适当的研究研究。由国际公认的病理学家商定的每个样本的诊断可供进行分子生物学、治疗、流行病学和其他研究的研究小组使用。CTB提供了使用资源材料进行的研究所产生的研究数据的档案。这一数据可能与核事故放射性尘埃暴露的预后和风险评估有直接关系。CTB允许多名研究人员访问相同的材料，允许对同一分子标记的不同技术进行比较，并分析多个分子标记。它为将来研究更多的标记(尚不清楚)提供了机会。存在一些类似的项目，以收集特定患者群体的生物档案。然而，这些项目中很少有项目从一开始就试图对收集的样本产生的研究数据进行整理。这份档案的不同之处在于，它处理的是一种相对罕见的肿瘤，其病因已知(暴露在放射性尘埃中)，因此能够研究环境和生理的相互作用，很可能许多涉及甲状腺癌发生的机制与其他癌症相同。因此，由这一资源支持的研究可能对治疗其他组织中的癌症有其他好处。

DESCRIPTION (provided by applicant): The main objective of this project is to provide a research resource (the Chemobyl Tissue Bank: CTB) for both ongoing and future studies of the health consequences of the Chemobyl accident. It seeks to maximize the amount of information obtained from small pieces of tumor by providing multiple aliquots of RNA and DNA extracted from well-documented pathological specimens to a number of researchers worldwide and to conserve this valuable material for future generations of scientists. It exists to promote collaborative, rather than competitive, research on a limited biological resource. The CTB ensures that the best possible diagnostic service is provided to patients and that appropriate ethical consent is obtained for each biological sample, that specimens are properly documented and sampled and that biological materials are available for appropriate research studies. A diagnosis for each sample, agreed by internationally recognized pathologists, is made available to research groups carrying out molecular biological, therapeutic, epidemiological and other studies. The CTB provides an archive of research data generated from research studies carried out using the resource material. This data may have direct relevance to both prognosis and assessment of risk from exposure to radioactive fallout from a nuclear accident. The CTB allows multiple researchers access to the same material, permitting comparison of different techniques for the same molecular marker and analysis of multiple molecular markers. It provides the opportunity for additional markers (as yet unknown) to be studied in the future. A number of similar projects to amass biological archives from specific patient groups exist. However, few of these projects seek, from their outset, to collate research data produced from the samples collected. This archive is different in that it deals with a relatively rare tumor whose a etiology is known (exposure to radio iodine in fallout), therefore enabling study of the interaction of environment and physiology, it is highly likely that many of the mechanisms involved in thyroid carcinogenesis are common to other cancers. The research supported by this resource may therefore have other benefits to the treatment of cancers in other tissues.