The Chernobyl Tissue Bank
The Chernobyl Tissue Bank
批准号:
7493248
负责人:
Geraldine Anne Thomas
金额:
$4.37万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-07-17 至 2008-08-31
关键词:
AccidentsAliquotArchivesBiologicalBiological MarkersBlood specimenCancer Research ProjectCollectionConsentCytembenaDNADataDevelopmentDiagnosisDiagnostic ServicesDiseaseEnsureEnvironmentEtiologyExposure toFreezingFutureFuture GenerationsGenerationsHealthMalignant NeoplasmsMalignant neoplasm of thyroidMolecularNuclear AccidentsNumbersOncogenicPathologistPatientsPhysiologyRNARadiationRadioactive FalloutResearchResearch PersonnelResourcesRisk AssessmentSamplingScientistSpecimenTechniquesTherapeuticThyroid GlandThyroid carcinomaTimeTissue BanksTissuescancer therapyinsightoutcome forecastresearch studytissue fixingtumor
中文摘要
这个项目的主要目标是提供一个研究资源(化学组织库:CTB),用于
正在进行的和未来对Chemobyl事故的健康后果的研究。它寻求
通过提供多份等量的信息,最大限度地增加从小块肿瘤获得的信息量
从有充分记录的病理标本中提取的RNA和DNA交给了一些研究人员
并为后代科学家保存这一宝贵的材料。它的存在是为了促进
在有限的生物资源上进行合作而不是竞争的研究。城规会确保
向患者提供尽可能好的诊断服务,并获得适当的伦理同意
每个生物样本,样本都有适当的文件和样本,生物材料
可用于适当的研究研究。每个样本的诊断,由国际商定
公认的病理学家,可供进行分子生物学、治疗、
流行病学和其他研究。C‘rB提供从研究中产生的研究数据的档案
使用资源材料进行的研究。这一数据可能与预后和
核事故放射性沉降物暴露风险的评估。
CTB允许多名研究人员访问相同的材料,允许对不同的
同一分子标记和多分子标记分析技术。它提供了
未来是否有机会研究更多的标记(尚不清楚)。一些类似的项目
收集特定患者群体的生物档案是存在的。然而,这些项目中很少有人寻求从
他们首先要整理从收集的样本中产生的研究数据。这个档案的不同之处在于它
研究的是一种病因已知的相对罕见的肿瘤(接触放射性碘的尘埃),因此
能够研究环境和生理的相互作用,很可能许多
甲状腺癌的发生机制和其他癌症一样。支持的研究
因此,这种资源可能对治疗其他组织中的癌症有其他好处。
英文摘要
The main objective of this project is to provide a research resource (the Chemobyl Tissue Bank: CTB) for
both ongoing and future studies of the health consequences of the Chemobyl accident. It seeks to
maximise the amount of informationobtained from small pieces of tumour by providing multiple aliquots of
RNA and DNA extracted from well documented pathologicalspecimens to a number of researchers
world-wide and to conserve this valuable material for future generations of scientists. It exists to promote
collaborative, rather than competitive, research on a limited biologicalresource. The CTB ensures that the
best possible diagnosticservice is provided to patients and that appropriate ethical consent is obtained for
each biologicalsample, that specimens are properlydocumented and sampled and that biological materials
are available for appropriate research studies. A diagnosis for each sample, agreed by internationally
recognised pathologists,is made available to research groups carrying out molecular biological, therapeutic,
epidemiological and other studies. The C'rB provides an archive of research data generated from research
studies carried out usingthe resource material. This data may have direct relevance to both prognosisand
assessment of riskfrom exposure to radioactive fallout from a nuclear accident.
The CTB allows multiple researchers access to the same material, permittingcomparison of different
techniques for the same molecular marker and analysis of multiple molecular markers. It provides the
opportunity for additional markers (as yet unknown) to be studied in the future. A number of similar projects
to amass biologicalarchives from specific patient groups exist. However, few of these projects seek, from
their outset, to collate research data produced fromthe samples collected. This archive is different inthat it
deals with a relatively rare tumourwhose aetiology is known (exposure to radioiodine in fallout), therefore
enabling study of the interactionof environment and physiology,it is highly likelythat many of the
mechanisms involved inthyroid carcinogenesisare common to other cancers. The research supportedby
this resource may therefore have other benefits to the treatment of cancers in other tissues.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ESTABLISH OF POST CHERNOBYL NIS THYROID BANKS
-
批准号:2879355
-
项目类别:
-
资助金额:$9.18万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:6803213
-
项目类别:
-
资助金额:$12.12万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:8547740
-
项目类别:
-
资助金额:$24.21万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:7434065
-
项目类别:
-
资助金额:$24.24万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:8425508
-
项目类别:
-
资助金额:$24.17万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:10219964
-
项目类别:
-
资助金额:$32.2万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:8895269
-
项目类别:
-
资助金额:$24.34万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:7937929
-
项目类别:
-
资助金额:$23.14万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:8144860
-
项目类别:
-
资助金额:$22.96万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:7122939
-
项目类别:
-
资助金额:$23.67万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:8723755
-
项目类别:
-
资助金额:$24.27万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:9751778
-
项目类别:
-
资助金额:$26.08万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:6687935
-
项目类别:
-
资助金额:$11.06万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:7681588
-
项目类别:
-
资助金额:$30.97万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:9051198
-
项目类别:
-
资助金额:$0.56万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank - Coordinating Center
-
批准号:9979765
-
项目类别:
-
资助金额:$25.21万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
ESTABLISH OF POST CHERNOBYL NIS THYROID BANKS
-
批准号:6377281
-
项目类别:
-
资助金额:$14.66万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
The Chernobyl Tissue Bank
-
批准号:6953036
-
项目类别:
-
资助金额:$11.71万
-
财政年份:2000
-
负责人:Geraldine Anne Thomas
-
依托单位:
海外基金