The Chernobyl Tissue Bank

这个项目的主要目标是提供一个研究资源(化学组织库：CTB)，用于 正在进行的和未来对Chemobyl事故的健康后果的研究。它寻求 通过提供多份等量的信息，最大限度地增加从小块肿瘤获得的信息量 从有充分记录的病理标本中提取的RNA和DNA交给了一些研究人员 并为后代科学家保存这一宝贵的材料。它的存在是为了促进 在有限的生物资源上进行合作而不是竞争的研究。城规会确保 向患者提供尽可能好的诊断服务，并获得适当的伦理同意 每个生物样本，样本都有适当的文件和样本，生物材料 可用于适当的研究研究。每个样本的诊断，由国际商定 公认的病理学家，可供进行分子生物学、治疗、 流行病学和其他研究。C‘rB提供从研究中产生的研究数据的档案 使用资源材料进行的研究。这一数据可能与预后和 核事故放射性沉降物暴露风险的评估。 CTB允许多名研究人员访问相同的材料，允许对不同的 同一分子标记和多分子标记分析技术。它提供了 未来是否有机会研究更多的标记(尚不清楚)。一些类似的项目 收集特定患者群体的生物档案是存在的。然而，这些项目中很少有人寻求从 他们首先要整理从收集的样本中产生的研究数据。这个档案的不同之处在于它 研究的是一种病因已知的相对罕见的肿瘤(接触放射性碘的尘埃)，因此 能够研究环境和生理的相互作用，很可能许多 甲状腺癌的发生机制和其他癌症一样。支持的研究 因此，这种资源可能对治疗其他组织中的癌症有其他好处。

The main objective of this project is to provide a research resource (the Chemobyl Tissue Bank: CTB) for both ongoing and future studies of the health consequences of the Chemobyl accident. It seeks to maximise the amount of informationobtained from small pieces of tumour by providing multiple aliquots of RNA and DNA extracted from well documented pathologicalspecimens to a number of researchers world-wide and to conserve this valuable material for future generations of scientists. It exists to promote collaborative, rather than competitive, research on a limited biologicalresource. The CTB ensures that the best possible diagnosticservice is provided to patients and that appropriate ethical consent is obtained for each biologicalsample, that specimens are properlydocumented and sampled and that biological materials are available for appropriate research studies. A diagnosis for each sample, agreed by internationally recognised pathologists,is made available to research groups carrying out molecular biological, therapeutic, epidemiological and other studies. The C'rB provides an archive of research data generated from research studies carried out usingthe resource material. This data may have direct relevance to both prognosisand assessment of riskfrom exposure to radioactive fallout from a nuclear accident. The CTB allows multiple researchers access to the same material, permittingcomparison of different techniques for the same molecular marker and analysis of multiple molecular markers. It provides the opportunity for additional markers (as yet unknown) to be studied in the future. A number of similar projects to amass biologicalarchives from specific patient groups exist. However, few of these projects seek, from their outset, to collate research data produced fromthe samples collected. This archive is different inthat it deals with a relatively rare tumourwhose aetiology is known (exposure to radioiodine in fallout), therefore enabling study of the interactionof environment and physiology,it is highly likelythat many of the mechanisms involved inthyroid carcinogenesisare common to other cancers. The research supportedby this resource may therefore have other benefits to the treatment of cancers in other tissues.