The Chernobyl Tissue Bank

该项目的主要目标是为以下研究提供研究资源（Chemobyl组织库：CTB）： 正在进行的和未来的关于Chemobyl事故对健康影响的研究。它寻求 通过提供多个等分试样， RNA和DNA提取自有据可查的病理标本RNA和DNA提取自有据可查的病理标本 并为未来的科学家保存这些宝贵的材料。它的存在是为了 合作，而不是竞争，对有限的生物资源的研究。CTB确保 为患者提供尽可能好的诊断服务，并获得适当的伦理同意， 每个生物样本，标本都有适当的记录和采样，生物材料 可用于适当的研究。对每个样本的诊断，由国际上同意 公认的病理学家，提供给研究小组进行分子生物学，治疗， 流行病学和其他研究。C'rB提供了一个由研究产生的研究数据档案 studies carried执行the resource资源material材料.这些数据可能与两个国家的经济和社会发展直接相关， 评估暴露于核事故放射性沉降物的风险。 CTB允许多个研究人员访问相同的材料， 同一分子标记分析技术和多个分子标记分析技术。它提供了 未来有机会研究其他标记物（尚不清楚）。多个类似项目 to amass积累biologicalarchives档案from specific特定patient患者groups组exist存在.然而，这些项目中很少有人寻求，从 他们的开始，整理研究数据从收集的样本。这个档案馆是不同的， 处理一种相对罕见的肿瘤，其病因是已知的（暴露于放射性碘的沉降物），因此， 为了研究环境和生理学的相互作用， 甲状腺癌发生的机制与其他癌症相同。该研究由 因此，这种资源可能对治疗其他组织中的癌症具有其他益处。

The main objective of this project is to provide a research resource (the Chemobyl Tissue Bank: CTB) for both ongoing and future studies of the health consequences of the Chemobyl accident. It seeks to maximise the amount of informationobtained from small pieces of tumour by providing multiple aliquots of RNA and DNA extracted from well documented pathologicalspecimens to a number of researchers world-wide and to conserve this valuable material for future generations of scientists. It exists to promote collaborative, rather than competitive, research on a limited biologicalresource. The CTB ensures that the best possible diagnosticservice is provided to patients and that appropriate ethical consent is obtained for each biologicalsample, that specimens are properlydocumented and sampled and that biological materials are available for appropriate research studies. A diagnosis for each sample, agreed by internationally recognised pathologists,is made available to research groups carrying out molecular biological, therapeutic, epidemiological and other studies. The C'rB provides an archive of research data generated from research studies carried out usingthe resource material. This data may have direct relevance to both prognosisand assessment of riskfrom exposure to radioactive fallout from a nuclear accident. The CTB allows multiple researchers access to the same material, permittingcomparison of different techniques for the same molecular marker and analysis of multiple molecular markers. It provides the opportunity for additional markers (as yet unknown) to be studied in the future. A number of similar projects to amass biologicalarchives from specific patient groups exist. However, few of these projects seek, from their outset, to collate research data produced fromthe samples collected. This archive is different inthat it deals with a relatively rare tumourwhose aetiology is known (exposure to radioiodine in fallout), therefore enabling study of the interactionof environment and physiology,it is highly likelythat many of the mechanisms involved inthyroid carcinogenesisare common to other cancers. The research supportedby this resource may therefore have other benefits to the treatment of cancers in other tissues.