Examining the Obesity Epidemic through Youth, Family, a*

描述（由申请人提供）： 该中心提案的目的是对青少年，家庭和年轻人的肥胖和癌症进行跨学科研究，培训和推广。该中心将解决有关青少年和家庭肥胖的病因，预防和治疗问题，并探索可能将肥胖与癌症联系起来的生物学途径。该中心的建议包括三个具体的研究项目。项目1是一项多因素、横断面和前瞻性的观察性研究，研究青少年肥胖发展的预测因素，包括社会文化因素、家庭因素、环境因素和个人因素。项目2是一项评估以家庭为基础的体重增加预防干预的研究，特别强调对体重增加的环境因素的干预。项目3是一项研究的影响，体力活动对雌激素代谢，氧化应激和DNA修复机制的年轻女性。三个R 01赠款将由一个核心，数据服务和分析核心支持。该提案还包括职业发展部分、为发展项目提供大量资金以及传播/翻译部分。总体目标是推进跨学科科学，促进对肥胖，青年，家庭和癌症的理解;支持该领域新研究人员的职业发展;并向更广泛的受众传播有关该主题的科学知识。

DESCRIPTION (provided by applicant): The purpose of this Center proposal is to conduct transdisciplinary research, training, and outreach on obesity and cancer in youth, family, and young adults. The proposed Center will address questions about the etiology, prevention, and treatment of obesity in youth and families, and explore biological pathways that may link obesity to cancer. The center proposal includes three specific research projects. Project 1 is a multifactorial, cross-sectional, and prospective observational study examining predictors of obesity development in adolescents, including sociocultural factors, family factors, environmental factors, and individual factors. Project 2 is a study evaluating family-base, weight-gain prevention intervention that particularly emphasizes intervention on environmental contributors to weight gain. Project 3 is a study of the effects of physical activity on estrogen metabolism, oxidative stress, and DNA repair mechanisms in young women. The three R01 grants will be supported by one core, a Data Services and Analysis Core. The proposal also includes a career development component, substantial funding for developmental projects, and a dissemination/translation component. The overall goals are to advance transdisciplinary science in the advancement of understanding of obesity, youth, family, and cancer; to support the career development of new investigators in the field; and to disseminate scientific knowledge about the topic to broader audiences.