Specialized Biodefense Training in Clinical/Translation

具体目标：该职业发展项目的具体目标是为健康提供高级培训 专业人员在生物防御和新发传染病临床研究中发挥领导作用。 促进临床和基础科学家之间的交流和合作，发展 了解公共卫生实践和政策，并建立联系，以促进 RCE基础科学家的翻译研究，特别是在诊断学的开发和试验中， 疫苗和疗法。 目标、设计和方法：该计划的目标将是培训个人能够 进行临床/转化性研究，例如增加政府、行业中的个人数量 以及擅长生物防御和新发传染病研究的学术界人士。一个 临床/转化科学研究职业发展计划将在加州大学设立 犹他州盐湖城的犹他州健康科学中心(UUHSC)。每年将有一名新的实习生， 无论是儿科传染病还是成人传染病，取决于资格培训 申请者。职业发展实习生将完成一年的临床传染病培训 UHSC或其他类似项目。然后，他们将接受为期两年的生物防御训练 由以下要素组成的计划： 1.生物安全与伦理必修课。伦理学课程是#年培训计划的一部分。 所有受训人员都将参与的临床调查(见下文第3项)。生物安全培训将 由丹佛健康医疗科罗拉多培训中心的视频会议提供 中心。 2.临床微生物学/病毒学实验室培训：研究员将进行为期一个月的临床培训 大学附属实验室微生物学/病毒学诊断实验室轮换， 在Cathy Petti博士的指导下，联合地区和大学病理学家(ARUP)， 盖尔·伍兹和大卫·希尔亚德。根据具体情况，提供额外的实验室培训 候选人，可通过犹他州卫生微生物学/病毒学部门获得 实验室和人类毒理学中心。 3.临床研究培训计划(TPCI)。 学员将报名参加提供的两个临床研究研究生培训计划之一 由TPCI所提供。第一个轨道强调人类疾病的遗传基础。第二 强调流行病学、临床结果、临床试验、医疗信息学和卫生服务 研究。 4.研究课题。将为每个受训人员指定一名导师来帮助他或她进行研究 符合受训者特定目标的项目。每个实习生将花费最多两年的时间 完成这项研究。在此期间，实习生将被鼓励发展独立的 项目，并在NIAID K02、K08、K23、K24或R01奖项的支持下申请支持，如 恰如其分。学员应申请在全国会议上展示他们的研究成果。

Specific Aim: The specific aim of this career development project is to provide advanced training for health professionals to assume a leadership role in biodefense and emerging infectious disease clinical research. Facilitation of communication and collaborations between clinical and basic scientists, development of understanding of public health practice and policy, and establishment of connections to facilitate the translational research of the RCE basic scientists, especially in development and trials of diagnostics, vaccines and therapeutics. Objectives, design and methods: The objective of the program will be to train individuals to be able to perform clinical/translational research such as to augment the number of individuals in government, industry and academia who are skilled in biodefense and emerging infectious disease research. A clinical/translational sciences research career development program will be established at the University of Utah Health Sciences Center (UUHSC) in Salt Lake City, Utah. There will be one new trainee per year, either in Pediatrics Infectious Diseases or Adult Infectious Diseases, depending on the training of qualifying applicants. Career development trainees will have completed a year of clinical infectious diseases training at the UUHSC or at a comparable program elsewhere. They will then take a two year biodefense training program composed of the following elements: 1. Required Courses in Biosafety and Ethics. A course in ethics is part of the Training Program in Clinical Investigation in which all trainees will participate (see item #3 below). Biosafety training will be provided by videoconference from the Colorado Training Center at the Denver Health Medical Center. 2. Clinical Microbiology/Virology Laboratory Training: Fellows will have a month-long clinical microbiology/ virology diagnostic laboratory rotation at the University-affiliated laboratory, Associated Regional and University Pathologists (ARUP) under the direction of Drs. Cathy Petti, Gail Woods and David Hillyard. Additional laboratory training, as appropriate for the particular candidate, is available through the Utah State Department of Health Microbiology/Virology Laboratory and the Center for Human Toxicology. 3. Training Program in Clinical Investigation (TPCI). Trainees will enroll in one of the two post-graduate training programs in clinical investigation offered by the TPCI. The first track emphasizes the inherited basis of human disease. The second emphasizes epidemiology, clinical outcomes, clinical trials, medical informatics and health services research. 4. Research Project. A mentor will be identified for each trainee to help him or her develop a research project that will fit the particular goals of the trainee. Each trainee will spend up to two years to complete this research. During this time, the trainee will be encouraged to develop an independent project and apply for support under the auspices of an NIAID K02, K08, K23, K24, or R01 award, as appropriate. Trainees should apply to present their research results at a national meeting.