Detecting and Monitoring Prostate Cancer Metastasis Using 41Ca and AMS

描述（由申请人提供）：本R21是为了响应PA-04-146泌尿外科试点和可行性计划而编写的。我们的长远目标是开发一种检测前列腺癌骨转移的新技术，并建立一种机制来监测治疗的成功，以防止癌症引起的骨质流失，我们将通过使用41ca和加速器质谱法直接量化骨代谢来实现这一目标。利用我们实验室开发的转移性人前列腺癌动物模型，我们将建立使用41ca诊断和监测骨转移治疗的可行性。此外，我们将开始在前列腺癌转移高风险患者中进行人体实验，以提供必要的数据和经验，以证明进一步的人体临床研究（例如RO1）。我们的最终目标是收集足够的数据，以保证将41ca纳入一项多地点临床试验，以检查双膦酸盐在治疗和预防前列腺癌转移中的使用。

DESCRIPTION (provided by applicant): This R21 is written in response to PA-04-146 Pilot and Feasibility Program in Urology. Our broad, long term objectives are to develop a new technology for detecting prostate cancer metastasis to bone and to establish a mechanism for monitoring success of therapy to prevent cancer induced bone loss, We will accomplish this goal by directly quantifying bone metabolism using 41 Ca and accelerator mass spectrometry. Using an animal model of metastatic human prostate cancer developed in our laboratory, we will establish the feasibility of using 41 Ca to diagnose and monitor therapy for bone metastasis. In addition, we will begin human experiments in patients at high risk of developing prostate cancer metastasis to provide the necessary data and experience to justify further human clinical studies (e.g. RO1). Our eventual goal is to gather sufficient data to warrant inclusion of 41 Ca in a multi-site clinical trial examining the use of bisphosphonates in the treatment and prevention prostate cancer metastasis.