Wireless Movement Disorder Monitor

描述(由申请人提供)：目标是设计、构建和临床评估一种专为帕金森氏病(PD)量身定做的无线运动障碍监测器(WMDM)。影响生活质量的主要帕金森病症状包括震颤、运动迟缓、僵硬和运动障碍。客观地量化症状将有助于评估治疗方案的疗效。在家中监测症状将使临床医生能够捕获复杂的波动模式，以响应治疗方案。第一阶段说明，震颤和运动迟缓的严重程度可以通过使用加速计和陀螺仪的小型、轻便、非束缚的手指佩戴系统进行监测。在第二阶段，我们将升级硬件和软件，并完成一项大型临床试验。一种新的无线电和安装设计将提供一个更小、更舒适的不受限制的患者单元。升级后的软件界面将包括临床视频、患者数据库和远程数据访问。新的检测算法将包括运动障碍检测。WMDM将在临床和帕金森病患者的家中进行临床测试。我们假设WMDM将捕获与震颤、运动迟缓、僵硬和运动障碍的定性临床评分相关的症状变量。此外，WMDM应在系统接受度较高的帕金森病患者家中成功使用

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a Wireless Movement Disorder Monitor (WMDM) specifically tailored to Parkinson's disease (PD). Major PD symptoms that affect quality of life include tremor, bradykinesia, rigidity, and dyskinesias. Objectively quantifying symptoms would aid in evaluating efficacy of treatment protocols. Monitoring symptoms at home would allow clinicians to capture complex fluctuation patterns in response to treatment protocols. Phase I illustrated that severity of tremor and bradykinesia could be monitored using a small, lightweight, untethered finger worn system utilizing accelerometers and gyroscopes. During Phase II we will upgrade the hardware and software and complete a large clinical trial. A new radio and mounting design will provide a smaller and more comfortable untethered patient unit. The upgraded software interface will include clinical video, a patient database, and remote data access. New detection algorithms will incorporate dyskinesia detection. The WMDM will be clinically tested both in the clinic and in the homes of PD subjects. We hypothesize that the WMDM will capture symptom variables that correlate to qualitative clinical scoring of tremor, bradykinesia, rigidity, and dyskinesias. In addition, the WMDM should be successfully used in the homes of PD subjects with high system acceptance