SCORE Project at Meharry Medical College-Supplement I

描述（由申请人提供）：梅哈里医学院SCORE项目的长期目标是帮助提高学校研究企业相对于美国其他健康科学中心的竞争地位。该计划旨在创造一个研究环境，使教师能够提高他们的研究技能和能力，从而有效地进行高质量的研究，通过同行评审的出版物和在国家会议上的演讲来传播他们的研究，并在独立的校外研究基金中取得更大的成功。最后，这项SCORE补充申请中正在进行的和拟议的研究项目将协助该机构开展基础、临床和应用研究，特别强调对少数民族人口造成不成比例影响的疾病和状况。该计划的具体目标是：1)提高MBRS研究人员同行评审出版物的科学生产力，从每三年大约四篇论文（资助年28-30）提高到平均每三年六篇论文（资助年32-34），2)到第34年，将与SCORE计划相关的研究人员获得的研究者发起的资助从10%增加到20%。

DESCRIPTION (provided by applicant): The long-range goal of the SCORE Program at Meharry Medical College is to assist in improving the competitive status of the school's research enterprise relative to other health science centers in the United States. The program seeks to create a research environment wherein faculty will improve their research skills and capabilities to efficiently conduct high quality research, to disseminate their research through peer-reviewed publications and presentations at national meetings, and to compete with greater success for independent extramural research funds. Finally, research projects ongoing and proposed in this SCORE supplemental application will assist the institution in its mission to conduct basic, clinical and applied research with special emphasis on diseases and conditions that disproportionately affect ethnic minority populations. The specific aims of the program are: 1) to increase the scientific productivity in terms of peer reviewed publications by MBRS investigators from approximately four papers per three years (grant years 28-30) to an average of six papers per three years (grant years 32-34), and 2) to increase the acquisition of investigator initiated grants from 10% to 20% of the investigators associated with the SCORE program by year-34. Eight regular subprojects and two pilot projects were funded in 2003 (year-32) as a result of the competing continuation application. One of the regular projects was funded as a R01 in 2004 and has been withdrawn. This supplemental application requests support for eleven regular research projects and two pilot projects. Projects are submitted from the School of Medicine departments of Biochemistry, Family and Preventive Medicine, Microbiology, Pharmacology, Physiology and Surgery. Thus the program is projected to focus on a broad spectrum of health related issues including cancer, sickle cell disease, signaling and transduction mechanisms, oral health, infectious diseases including HIV/AIDS and neuroscience.