Core D: Animal Models and Pathology

埃默里大学分子生物学和病理学专业资源（核心D） 翻译成像中心（EMTIC）将通过在两个关键领域提供服务， 领域：动物模型和组织病理学服务。核心是成功的必要条件， EMTIC是高度综合性的，被所有三个研究项目和所有五个试点项目所利用。 动物模型组件将用于生成和表征用于分子生物学的新型啮齿动物模型。 成像在癌症研究中的应用，并将通过收集和分析肿瘤来协助个人项目。 这些动物的数据。癌症相关动物模型的产生和分析是癌症研究的核心。 EMTIC由于高度重视开发和验证新型示踪剂， 临床前研究，可用作肿瘤检测、进展和 体内传播。动物部分也将作为一个保存库， 分发可能用于项目和试点项目的任何新的转基因小鼠品系， 它们成为必要的。中心将进行尸检和组织采集，用于实验 动物，并将从选定的动物中收集肿瘤样品，用于产生细胞系， 项目调查员。核心的病理学部分将提供组织和肿瘤采购 专业知识、组织处理以及肿瘤的组织学和免疫组织化学分析 人类疾病和动物模型的样本。组织学和免疫组化评价 为了关联和验证来自患者和动物模型的肿瘤， 通过PET、MRI和光学方法用组织中的靶向生物标志物检测新示踪剂。 动物模型和病理学核心将为EMTIC的总体目标做出重大贡献 通过提供这些服务和专业知识，从科学的角度。此外，包括 将这些服务合并为一个全面的核心组成部分，将为EMTIC提供额外的好处， 通过整合努力，避免不必要的实验重复， 利用核心人员的集体专业知识。

The Animal Models and Pathology Specialized Resource (Core D) of the Emory Molecular and Translational Imaging Center (EMTIC) will assist the overall project by providing service in two critical areas: animal models and histopathologic services. The Core is necessary for the success of the EMTIC and is highly integrative, being utilized by all three research projects and all five pilot projects. The animal models component will act to generate and characterize novel rodent models for molecular imaging in cancer research and will assist the individual projects by collecting and analyzing tumor data from these animals. The production and analysis of relevant animal models of cancer is central to the EMTIC because of the heavy emphasis on the development and validation of novel tracers in preclinical studies that could be utilized as markers for tumor detection, progression, and dissemination in vivo. The animal component will also serve as a repository for the preservation and distribution of any novel transgenic strains of mice that may be utilized in projects and pilot projects as they become necessary. The Core will perform necropsy and tissue collection for experimental animals, and will collect tumor samples from selected animals for generation of cell lines for use by project investigators. The pathology component of the Core will provide tissue and tumor procurement expertise, tissue processing, as well as histological and immunohistochemical analysis of tumor samples from human disease and animal models. Histologic and immunohistochemical evaluation of tumors from patients and animal models will be necessary in order to correlate and validate the detection of novel tracers by PET, MRI, and optical methods with the targeted biomarkers in tissues. The Animal Models and Pathology Core will contribute significantly to the overall goals of the EMTIC from a scientific perspective by providing these services as well as expertise. In addition, the inclusion of these services into a comprehensive core component will provide additional benefit to EMTIC as a whole, through consolidation of effort, avoidance of unnecessary experimental duplication and by drawing upon the collective expertise of the Core personnel.