Core--Outcome Measures and Cell Preparation

核心B提供了用于治疗的细胞以及计划项目所有组成项目的基本结果测量。神经功能和行为是项目1（MSC治疗卒中）和项目2（MSC治疗创伤性脑损伤）的主要结局指标，并广泛用于项目3（MSC与组织相互作用的分析）。在这个核心，我们描述了一套功能测试，以评估MSC治疗的反应。包括在电池的测试是，运动和体感测试，和神经系统的规模。项目1-3还讨论了注射的MSC的命运，这些细胞产生的因子及其对脑组织的影响，促进改善功能结果，以及MSC对内源性实质细胞的影响。该核心提供细胞鉴定、营养因子测量和鉴定以及显微镜检查所需的所有资源。这三个项目都使用骨髓基质细胞。核心B，提供专用于这些细胞的生产和表征的设施和人员。将所需资源集中用于核心B的组成项目，可以高效率和有效地利用所有三个项目所必需的资源。

Core B provides the cells to be employed for treatment as well as the essential outcome measurements for all constituent projects of the Program Project. Neurologic function and behavior are the primary outcome measures for Project 1 (Treatment of Stroke with MSCs) Project 2 (Treatment of Traumatic Brain Injury with MSCs) and are extensively employed in Project 3 (Analysis of MSC Interaction with Tissue). In this core, we describe the sets of functional tests to be employed in evaluating response to MSC therapy. Included in the battery of tests are, motor and somatosensory tests, and neurological scales. Projects 1-3 also address the fate of the injected MSCs, the factors produced by these cells and their effect on cerebral tissue that promote improved functional outcome, and the effects of MSCs on the endogenous parenchymal cells. This core provides all the resources required for cellular identification, measurement and identification of trophic factors, and microscopy. All three projects employ marrow stromal cells. Core B, provides the facilities and personnel dedicated to the production and characterization of these cells. Focusing resources needed for the component projects in Core B, allows for efficient and effective utilization of resources essential for all three projects.