Core--Clinical and biometric

临床核心中心成立于1992年，是在之前的一个计划项目的支持下成立的，是招募、评估和转介受试者参加该计划的人类受试者调查的最有效机制，并用于建立和管理关于患者和对照的临床、人口和心理社会信息的永久数据库，供研究人员使用。在即将到来的资助中，生物识别部分将被纳入这个核心中 句号。核心将继续进行主题管理、与登记对象进行季度联系以及网上数据收集，以支持正在进行的对战区导弹防御系统发展风险因素的纵向前瞻性研究(迈克斯纳的子项目)。此外，核心将负责招募、数据库创建和管理参与迈克斯纳、霍林斯和埃西克的子项目的所有疼痛机制研究的受试者。因此，该核心的具体目标和职能是： 1.招募并确认TMD患者、纤维肌痛(FM)患者和健康受试者的诊断。在筛查访问之前，将进行电话筛查以确定排除标准，筛查访问将包括医疗保健专业人员的病史和诊断性体检，以及填写人口统计和健康史问卷。 2.通过安排迈克斯纳、霍林斯和埃西克的子项目中的筛查访问和测试会议；在适当的情况下随机安排受试者参加测试方案；以及监测方案的遵守情况，协调受试者对人体研究的参与。 3.对于Maixner的子项目，协调随机分配β-肾上腺素能阻滞剂和安慰剂；并监测受试者的药物副作用。 4.监督与研究询问有关的患者和健康受试者的数据收集、录入、处理、存储和分发给调查人员。 5.协助调查人员设计和执行对研究数据进行统计分析的计划，并解释结果。

The Clinical Core was founded in 1992 under the auspices of a previous Program Project as the most efficient mechanism for recruiting, evaluating and referring subjects to the Program's human subjects investigations and for establishing and managing a permanent database of clinical, demographic, and psychosocial information on patients and controls for use by the investigators. A biometric section will be incorporated in this core in the upcoming funding period. The core will continue subject management, quarterly contacts with enrolled subjects, and web-based data collection to support the ongoing, longitudinal prospective study of risk factors in the development of TMD (Subproject by Maixner). In addition the core will be responsible for the recruitment of, and database creation and management of subjects participating in all the Pain Mechanisms Studies of Subprojects by Maixner, Hollins, and Essick. Accordingly, the specific aims and function of this core are to: 1. Recruit and confirm a diagnosis for TMD patients, fibromyalgia (FM) patients, and healthy subjects. A phone screening for exclusion criteria will precede a screening visit that will include a medical history and diagnostic physical exam by a health care professional, as well as completion of demographic and health history questionnaires. 2. Coordinate subjects' participation in the human studies by scheduling screening visits and testing sessions in Subprojects by Maixner, Hollins, and Essick; by randomizing subjects to testing protocol, where appropriate; and by monitoring compliance with protocols. 3. For Subproject by Maixner, coordinate randomization and dispensing the beta-adrenergic blockade agent and placebo; and monitor subjects for drug side effects. 4. Oversee data collection, entry, processing, storage, and distribution to the investigators from patients and healthy subjects relevant to their research inquiries. 5. Assist investigators in designing and implementing plans for statistical analyses of research data, and in the interpretation of results.