A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models

描述（由申请人提供）：现代医学科学依赖于动物模型，用于基础研究和新干预措施和药物的评估。各种生物学问题的生理学研究通常需要在动物研究中收集生物物理和生物化学参数。通常，最初的实验是在小型哺乳动物，如小鼠或大鼠中进行的，新的范例涉及小鼠和大鼠的品系和亚品系的比较，以确定变异性的遗传来源。将传感器输出传输到外部环境的可用技术涉及电线连接和约束栓系，其限制动物移动和记录条件，或涉及1-3个通道的固定集成无线系统，一次仅适用于1只动物。需要研究随时间的生理变化以评估疾病进展（或消退）或药物作用，并且此类研究优选在不受限制和未麻醉的啮齿动物中进行。目前的技术限制是芯片技术和多个可修改的传感器之间的接口。目前的连接器不能适应睡眠、心率、温度等记录的定制放置，因此限制了实用性，增加了动物使用，并使技术过度专业化到独特的地点。纳米元件有限公司，与凯斯西储大学合作，提出开发一种无线、多通道遥测生物传感器，用于可进行基因解剖的动物模型研究。该微系统是参数传感器和外部环境之间的接口。多通道意味着最少4个输入通道，可以扩展到8个或更多通道。具体而言，将开发用于生物电位、温度和压力的多通道无线遥测微系统。将考虑其他潜在的生化参数。将这些生物物理和生物化学参数集成到多通道无线遥测微系统中是本研究的最终目标。这项拟议中的研究将促进动物研究，这可能会导致更好地了解睡眠障碍和潜在的新干预措施。

DESCRIPTION (provided by applicant): Modern medical science is dependant upon animal models, for both basic research and evaluation of new interventions and drugs. Physiological investigation of various biological issues commonly requires the collection of biophysical and biochemical parameters in animal studies. Typically initial experiments are carried out in small mammals, such as a mouse or rat, and new paradigms involve the comparisons of strains and sub-strains of mice and rats to identify genetic sources of variability. Available techniques to transmit the sensor outputs to the external environment involve wire connections and restraint tethering, which limit animal movement and recording conditions, or involve fixed integrated wireless systems of 1-3 channels, applicable to only 1 animal at a time. Studies of physiologic variations over time are needed to assess disease progress (or regression) or drug effects, and such studies are preferably performed in the unrestrained and unanaesthetized rodent. The current limitation of technology is the interface between chip technology and multiple and modifiable sensors. Connectors at present cannot accommodate the tailored placements of recording for sleep, heart rate, temperature, etc, and thus limit utility, increase animal use, and overspecialize the technology to unique sites. Nanocomponent, Ltd., in partnership with Case Western Reserve University, proposes to develop a wireless, multi-channel telemetric biosensor for research in animal models amendable to genetic dissection. This microsystem is an interface between the parameter sensors and the external environment. The multi-channels means a minimum of 4 input channels and can extend to 8 or more channels. Specifically, multi-channel wireless telemetric microsystems for biopotentials, temperature, and pressure will be developed. Other potential biochemical parameters will be considered. Integration of these biophysical and biochemical parameters into a multi-channel wireless telemetric microsystem is the ultimate goal of this research. The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions.