New Ruthenium Carbene Complexes for Olefin Metathesis

描述（由申请人提供）：本文所述的研究计划旨在制备具有新型配体的钌配合物，以实现合成有用的复分解反应。具体来说，我们将致力于稳定甲基配合物，以开发实际的乙醇水解反应，并设计一组手性配体，以完成对映选择性复分解反应。乙烯解是一种交叉复分解反应，其中乙烯被用作交叉伙伴，在有机合成中用于脱同源烯烃，并作为一种降解工具来确定天然产物的结构。通用对映选择性催化剂的开发将进一步扩大烯烃复分解在有机化学和聚合物化学中的适用性。为了实现这些目标，将探索新的碳配体结构。

DESCRIPTION (provided by applicant): The research proposal described herein is aimed at the preparation of ruthenium complexes with novel ligands to effect synethetically useful metathesis reactions. Specifically, efforts will be focused on the stabilization of a methylidene complex for the development of a practical ethenolysis reaction, and the design of a chiral ligand set in order to accomplish enantioselective metathesis reactions. Ethenolysis, the cross metathesis reaction where ethylene is used as the cross-partner, is useful in organic synthesis to dehomologate olefins, and as a degradation tool to determine the structure of natural products. The development of general enantioselective catalysts would further extend applicability of olefin metathesis in organic and polymer chemistries. New carbene ligand architectures will be explored in order to realize these goals.