Developing and Improving Fox Chase's Animal Resources

描述(由申请人提供)： 福克斯·蔡斯癌症中心的实验动物设施多年来一直为研究人员提供优质的动物护理和支持，自1969年首次申请以来，一直享有国际实验动物护理评估与认可协会(AAALAC)的全面认可。从那时起，该研究所和动物研究项目得到了显著的发展，成功地整合了新装修的5800平方米。英国《金融时报》SPF研究屏障设施和新创建的1300平方米。英国《金融时报》隔离设施。多年来，随着物理结构的显著改善，提供了例行维护，但笼式清洗设备已经使用了20年，越来越不可靠。维修和适当卫生条件保险的停工时间导致向动物饲养室运送用品的延误，并增加了动物护理人员的维护费用和加班费。动物护理计划的不断扩大需要这一功能的现代化，并配备更高效和可靠的设备。因此，我们要求提供经费，用于购买两台隧道清洗机、一台行李架清洗机、一台床上用品分配器和一个瓶子灌装站。自1999年以来，用于资助研究的老鼠笼的数量增加了115%，目前动物饲养设施已达到饱和；预计未来将以每年18%的速度增长。高密度微型隔离架的系统采购已经开始，但目前的采购率不足以满足不断增长的啮齿动物数量。为了向免疫缺陷动物研究屏障中的重要研究动物提供笼级保护，并增加研究啮齿动物种群，要求为额外的四个通风笼子单元和两个HEPA过滤更换罩提供资金。这将是提高研究啮齿动物住房质量和数量的总体计划的重要一步。

DESCRIPTION (provided by applicant): The Laboratory Animal Facility at the Fox Chase Cancer Center has provided excellent quality animal care and support to research investigators for many years, and has enjoyed Full Accreditation by the Association for the Assessment and Accreditation for Laboratory Animal Care International (AAALAC) since its first application in 1969. Since that time, the institute and the animal research programs have grown significantly, with the successful integration of a newly renovated 5800 sq. ft. SPF Research Barrier facility and a newly created 1300 sq. ft. quarantine facility. Routine maintenance has been provided over the years with significant improvements to the physical structures, but the cage wash equipment has been in use for 20 years and is increasingly unreliable. Downtime for repairs and insurance of proper sanitation conditions has resulted in delays in the delivery of supplies to animal rooms and increased costs for maintenance and for overtime salaries of animal care staff. The continuing expansion of the animal care program necessitates the modernization of this function with more efficient and reliable equipment. We are therefore requesting funds for two tunnel washers, one rack washer, one bedding dispenser and one bottle filling station. The number of mouse cages used in funded research has increased 115% since 1999 and has filled the animal holding facility to capacity at the present time; an annual increase of 18% is projected for the future. The systematic purchase of high-density microisolator racks has begun but the current rate of purchase is inadequate to meet the increasing rodent population. In order to provide cage level protection to the important research animals maintained in the immunodeficient animal research barrier and increase the research rodent population funding is requested for four additional ventilated caging units and two HEPA filtered change hoods. These will be a major step in an overall plan to improve the quality and increase the quantity of housing for research rodents.