American Trypanosoma and Leishmania are the causative agents of two of 17 Neglected Tropical Diseases

以缺乏控制措施和对发展中国家产生重大影响为特征的一系列感染。这些昆虫媒介传播的原生动物分别是恰加斯病和利什曼病的病因。尽管最近在病媒控制等领域作出了努力，但由克氏锥虫引起的恰加斯病和由利什曼原虫引起的利什曼病的病例仍然很高，分别高达每年700万感染病例和170万新病例。迫切需要确定和验证新的药物靶点，这就是当前项目的目标。

a collection of infections characterized by a lack of control measures and major impacts on developing nations. These insect vector borne protozoa are the cause of Chagas Disease and leishmaniasis respectively. Despite recent efforts in areas such as vector control, cases of Chagas Disease, caused by Trypanosoma cruzi and leishmaniasis, caused by Leishmania spp, remain high - up to 7M infected and 1.7M new cases per year respectively. There is an urgent need to identify and validate new drug targets and this is what the current project aims to do.