Understanding and manipulating how Trypanosoma cruzi infects its triatomine insect hosts
了解和操纵克氏锥虫如何感染其锥蝽昆虫宿主
基本信息
- 批准号:BB/Y001125/1
- 负责人:
- 金额:$ 49.71万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Chagas disease, also known as American trypanosomiasis, results in approximately 10,000 deaths annually. It is caused by the protozoan parasite Trypanosoma cruzi. An estimated 6 to 7 million people worldwide are infected with T. cruzi but, despite these large numbers, Chagas disease is a neglected tropical disease for which there are no successful vaccines. The disease is endemic to 21 continental Latin American countries and is mostly transmitted when humans come into contact with faeces and/or urine of infected blood-sucking triatomine bugs, primarily Rhodnius prolixus and Triatoma infestans (vector-borne transmission). We know that the parasite utilises various mechanisms to evade the mammalian host immune system including producing signalling molecules termed lipid mediators that serve to dampen the host immune response. However, just how the parasite establishes itself in the insect host has not been elucidated. Our preliminary data indicates that the production of lipid mediators by insect-infective forms of the parasite likely plays a vital role and exploring this is a focus of the current proposal. We will identify these lipid mediators and investigate how they regulate insect immunity. A critical step is the initial stage of infection, when the parasite establishes itself in the insect gut. Competing gut bacteria create a hostile environment for the parasite. To counter this, the parasite hacks the insect immune system so that the insect produces antimicrobial proteins to reduce the bacterial population in the gut. With BBSRC support, we previously developed and patented a novel technology to repurpose gut bacteria from these insects so that they continuously produce genetic information that can silence specific genes of the insect host. We now intend to apply this technology to target how the insect immune system is regulated. Our goal is to exploit this to counter how the parasite hacks the insect immune response. If successful, this approach will reduce parasite numbers in the insect which will, in turn, lower disease transmission by the vector. The project will demonstrate whether this approach has potential to be used as part of our response to combat climate-change associated increases in vector-borne disease transmission in general.
查加斯病,也称为美洲锥虫病,每年导致大约10 000人死亡。它是由原生动物寄生虫克氏锥虫引起的。据估计,全世界有600万至700万人感染了T。尽管有如此多的病例,但恰加斯病是一种被忽视的热带疾病,没有成功的疫苗。这种疾病在21个拉丁美洲大陆国家流行,主要是在人类接触受感染的吸血锥蝽的粪便和/或尿液时传播,主要是Rhodnius prolixus和Triatoma infestans(媒介传播)。我们知道寄生虫利用各种机制来逃避哺乳动物宿主免疫系统,包括产生称为脂质介质的信号分子,其用于抑制宿主免疫反应。然而,寄生虫如何在昆虫宿主中建立自己还没有被阐明。我们的初步数据表明,由寄生虫的昆虫感染形式产生的脂质介质可能起着至关重要的作用,探索这一点是目前建议的重点。我们将确定这些脂质介质,并研究它们如何调节昆虫免疫。一个关键步骤是感染的初始阶段,当寄生虫在昆虫肠道中建立自己。竞争的肠道细菌为寄生虫创造了一个敌对的环境。为了解决这个问题,寄生虫攻击昆虫的免疫系统,使昆虫产生抗菌蛋白,以减少肠道中的细菌数量。在BBSRC的支持下,我们之前开发并获得了一项新技术的专利,该技术可以重新利用这些昆虫的肠道细菌,使它们不断产生可以沉默昆虫宿主特定基因的遗传信息。我们现在打算将这项技术应用于昆虫免疫系统的调节。我们的目标是利用这一点来对抗寄生虫如何攻击昆虫的免疫反应。如果成功,这种方法将减少昆虫中的寄生虫数量,从而降低病媒的疾病传播。该项目将证明这种方法是否有潜力作为我们应对气候变化相关的一般病媒传播疾病传播增加的一部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Dyson其他文献
Mind the gap: a qualitative approach to assessing why different sub-cultures within high-risk industries interpret safety rule gaps in different ways
注意差距:采用定性方法评估高风险行业内不同亚文化为何以不同方式解释安全规则差距
- DOI:
10.1016/j.ssci.2016.11.002 - 发表时间:
2017 - 期刊:
- 影响因子:6.1
- 作者:
E. Lofquist;Paul Dyson;Sondre N. Trønnes - 通讯作者:
Sondre N. Trønnes
An exemplary scheme? An evaluation of the integrated children's system
一个示范性的计划?
- DOI:
10.1093/bjsw/bcp040 - 发表时间:
2009 - 期刊:
- 影响因子:1.8
- 作者:
I. Shaw;M. Bell;I. Sinclair;P. Sloper;W. Mitchell;Paul Dyson;J. Clayden;J. Rafferty - 通讯作者:
J. Rafferty
Correction: Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
- DOI:
10.1186/s13071-024-06492-2 - 发表时间:
2024-09-27 - 期刊:
- 影响因子:3.500
- 作者:
Norman A. Ratcliffe;Joao P. Furtado Pacheco;Paul Dyson;Helena Carla Castro;Marcelo S. Gonzalez;Patricia Azambuja;Cicero B. Mello - 通讯作者:
Cicero B. Mello
Paul Dyson的其他文献
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{{ truncateString('Paul Dyson', 18)}}的其他基金
Optimising symbiont-mediated RNA interference as a control measure for Western Flower Thrips and Tomato Spotted Wilt Virus
优化共生体介导的 RNA 干扰作为西花蓟马和番茄斑萎病毒的控制措施
- 批准号:
BB/R006148/1 - 财政年份:2018
- 资助金额:
$ 49.71万 - 项目类别:
Research Grant
China partnering: exploiting actinobacteria from extreme environments
中国合作:利用极端环境中的放线菌
- 批准号:
BB/J020419/1 - 财政年份:2012
- 资助金额:
$ 49.71万 - 项目类别:
Research Grant
A pipeline technology for discovery of new antibiotics from Streptomyces
从链霉菌中发现新抗生素的管道技术
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BB/H023747/1 - 财政年份:2011
- 资助金额:
$ 49.71万 - 项目类别:
Research Grant
Developing a Gene Silencing Technology for Insect Vectors of Disease
开发疾病昆虫媒介基因沉默技术
- 批准号:
BB/G024154/1 - 财政年份:2009
- 资助金额:
$ 49.71万 - 项目类别:
Research Grant
Systematic mutagenesis of the model organism Streptomyces coelicolor: completion of an essential resource for the research community
模式生物天蓝色链霉菌的系统诱变:完成研究界的重要资源
- 批准号:
BB/E019242/1 - 财政年份:2007
- 资助金额:
$ 49.71万 - 项目类别:
Research Grant
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