Sympathetic Nervous System & Metabolism in Older Humans

描述(申请人提供)：候选人克里斯托弗·贝尔博士，生理学家，目前由美国心脏协会的个人博士后奖学金资助。贝尔博士过去和现在的研究重点一直是生理衰老对休息和运动能量消耗的影响。他的眼前目标是获得新的研究和专业技能，以帮助他实现他的长期目标，即开发一个成功的独立的、由外部资金资助的老龄研究项目。拟议的K01发展计划应该为贝尔博士提供必要的培训，以实现他的目标。 职业发展计划-贝尔博士建议的研究职业发展活动包括：1)获得与建议研究计划相关的新的研究技能，并对其进行补充；2)组织活动，包括正式的课程工作；出席期刊俱乐部、研讨会系列和科学会议并发表演讲；以及与他的指导团队定期互动。总体计划建立在“翻译研究”培训模式的基础上。 环境-贝尔博士的研究培训环境应该是突出的。发起人道格拉斯·西尔斯博士是一位知名的外部资助科学家，在生物医学衰老研究方面有着成功的指导记录。他还得到了几位咨询导师的补充，他们将在培训计划的特定领域提供指导。老龄化研究方面的其他教员改善了当地的培训环境。 研究-这项研究的总体目的是增加我们对成年人类β-肾上腺素能受体交感神经系统(β-AR SNS)、静息代谢率(RMR)调节和产热随年龄变化的机制的了解。我将确定能量流动(处于能量平衡时的饮食摄入量和能量消耗水平)、增加的β-AR反应性和β-AR基因变异对中老年人类RMR和产热的β-AR SNS支持的影响。

DESCRIPTION (provided by applicant): Candidate - The candidate, Christopher Bell, Ph.D., is a physiologist currently supported by an individual postdoctoral fellowship from the American Heart Association. Dr. Bell's past and current research focus has been on the effect of physiological aging on resting and exercise energy expenditure. His immediate goal is to acquire new research and professional skills to help him achieve his long-term goal of developing a successful independent extramurally-funded research program in aging. The proposed K01 development plan should provide Dr. Bell with the necessary training to achieve his goal. Career Development Plan - Dr. Bell's proposed research career development activities consist of: 1) acquiring new research skills associated with and complementary to the proposed research plan; and 2) structured activities including formal course work; attendance and presentation at journal clubs, seminar series, and scientific meetings; and regular interactions with his mentoring team. The overall plan is based on a "translational research" training model. Environment - The environment for Dr. Bell's research training should be outstanding. The sponsor, Dr. Douglas Seals, is a well-established extramurally-funded scientist with a strong record of successful mentoring in biomedical aging research. He is complemented by several consulting mentors who will provide guidance in specific areas of the training plan. Other faculty in aging research enhances the local training environment. Research - The general aim of this research is to increase our understanding of the mechanisms responsible for changes in beta-adrenergic receptor sympathetic nervous system (beta-AR SNS) modulation of resting metabolic rate (RMR) and thermogenesis with aging in adult humans. I will determine the influence of energy flux (the level of dietary intake and energy expenditure while in energy balance), increased beta-AR responsiveness, and beta2-AR gene variants on beta-AR SNS support of RMR and thermogenesis in middle-aged and older adult humans.