ESTROGEN, INSULIN AND REGIONAL LIPOLYSIS IN OLDER WOMEN

描述(申请人提供)：女性绝经后体重增加 脂肪优先沉积在腹部，特别是腹内- 腹部。新陈代谢和心血管疾病的风险也会增加 绝经后的非线性。这项研究项目的中心主题是 是关于腹内脂肪(IAF)和雌激素在 女性全身和局部脂肪组织脂肪分解的调节。三 《特定目标》将针对绝经后女性提出以下假设： 1)IAF容量与胰岛素抵抗有关。 全身和局部脂肪组织的脂肪分解，2)常规使用 雌激素可以减轻胰岛素抑制脂解的这种抵抗，并且 3)IAF的降低将增强胰岛素的降脂作用。这个 申请者雷切尔·E·范·佩尔特博士目前由一名个人支持 来自NHLBI的NRSA，并展示了一贯的研究重点和记录 在研究年龄、运动和荷尔蒙相关变化方面的生产力 身体成分、新陈代谢和心血管疾病风险。她的职业目标 是成为一名独立的科学家，并开发一种由外部资金资助的 研究计划，继续专注于老年学研究。K01 导师研究科学家发展奖将为Van Pelt博士提供 受保护的研究时间以获得额外的研究技能和 实现这一目标所需的经验。除了解决 建议的具体目标，她培训的一个重要目标就是学习 具有技术挑战性的微透析和高胰岛素、正血糖 夹具程序，并获得基础工作台工作的进一步经验和 稳定的同位素动力学。在颁奖期间，范·佩尔特博士将 通过临床科学学院的临床科学证书计划课程 医学。她还将参加每周一次的研究研讨会， 期刊俱乐部和大型轮回，以及相关的年度科学 开会。范·佩尔特博士的赞助人温迪·M·科尔特博士是一位知名的 在老龄化研究方面的调查者和导师，并在 科罗拉多健康大学老年医学部 科学中心。她和部门将为Van Pelt博士提供有钱人 所需的学习环境、资源和技术指导 顺利完成培训和职业发展。

DESCRIPTION (provided by applicant): As women gain weight after the menopause fat is preferentially deposited in the abdominal, and particularly the intra- abdominal region. Risk of metabolic and cardiovascular disease also increases non-linearly after the menopause. The central theme of this research project is the study of the role of intra-abdominal fat (IAF) and estrogen in the regulation of whole body and regional adipose tissue lipolysis in women. Three specific aims will address the following hypotheses in postmenopausal women: 1) IAF volume is associated with resistance to insulin suppression of lipolysis in whole body and regional adipose tissue, 2) regular use of estrogen attenuates this resistance to insulin suppression of lipolysis, and 3) a reduction in IAF will enhance the antilipolytic action of insulin. The applicant, Rachael E. Van Pelt, PhD, is currently supported by an individual NRSA from NHLBI and has demonstrated a consistent focus and record of research productivity in the study of age-, exercise-, and hormone-related changes in body composition, metabolism and cardiovascular disease risk. Her career goal is to become an independent scientist and to develop an extramurally-funded research program to continue her focus in gerontologic research. The K01 Mentored Research Scientist Development Award would provide Dr. Van Pelt protected research time to obtain the additional research skills and experience necessary to achieve this goal. In addition to addressing the specific aims of the proposal, an important goal of her training is to learn the technically challenging micro dialysis and hyperinsulinemic, euglycemic clamp procedures, and to acquire further experience in basic bench work and stable isotope kinetics. During the award period Dr. Van Pelt will take courses through the Certificate Program in Clinical Science in the School of Medicine. She will also attend and participate in weekly research seminars, journal clubs and grand rounds, as well as relevant annual scientific meetings. Dr. Van Pelt's sponsor, Wendy M. Kohrt, PhD, is an established investigator and mentor in aging research and has a well-funded laboratory in the division of Geriatric Medicine at the University of Colorado Health Sciences Center. She and the department will provide Dr. Van Pelt the rich learning environment, resources, and technical guidance necessary to successfully complete her training and career development.