COBRE: UD: PROJ 1: HEALING OF CARTILAGE AFTER EXPERIMENTALLY INDUCED OA

我们建议在特拉华大学建立一个生物医学研究中心，专注于骨关节炎的预防和治疗。这项提案涉及三个研究项目，每个项目由一名初级教员领导，并由资深教员指导。在项目1中，马纳尔博士建议使用一种基于核磁共振和肌电数据的生物医学模型，在进行日常生活活动的同时检查膝关节运动学和动力学。项目2：鞋内楔形物已被证明是减少骨性关节炎患者疼痛的一种有效的保守方法。这种疼痛减轻的机制还不是很清楚。在我们的第三个项目中，Royer博士建议检查膝盖骨关节炎患者鞋内楔形物对静态对齐测量的影响。此外，还将检查这种治疗的长期效果。在项目3中，鲁道夫博士提议研究膝内翻(“弓腿畸形”)，这种疾病通常会导致膝关节内侧间隙的关节炎。对于膝内翻患者，通常会进行手术来纠正膝关节对齐，方法是移除膝关节正下方的胫骨外侧的一块楔骨，以更正常地对齐关节表面(闭合楔形截骨术)。摘除骨骼会增加膝关节周围关节囊、肌肉和韧带的松弛，并可能导致生物力学和肌肉反应问题的增加。作为一种替代手术，开口楔形截骨术涉及在胫骨内侧创造一个开口，随着时间的推移，这个开口可以慢慢分散。本研究的目的是研究截骨楔形截骨联合骨痂牵张矫正膝内翻手术前后运动和肌肉活动的差异。

We propose to establish a center of biomedical research excellence at the University of Delaware that will focus on the prevention and treatment of osteoarthritis. This proposal involves three research projects, each lead by a junior faculty member who will be mentored by senior faculty. In Project 1, Dr. Manal proposes to use a biomedical model based on MRI and electromyographic data to examine knee kinematics and kinetics while performing activities of daily living. Project 2: In-shoe wedges have been shown to be an effective conservative approach in reducing pain in patients with osteoarthritis. The mechanism responsible for this pain reduction is not well understood. In our third project, Dr. Royer proposes to examine the examine the effects of in-shoe wedges in patients with knee OA on static alignment measures. In addition, the long-term effect of this treatment will also be examined. In Project 3, Dr. Rudolph proposes to study genu varum ("bowleggedness"), which often leads to arthritis on the medial compartment of the knee. Surgery is often performed to correct the alignment of the knee in people with genu varum by removing a wedge of bone on the lateral side of the tibia just below the knee joint to align the joint surfaces more normally (closing wedge osteotomy). Removing bone can increase the laxity of the joint capsule, muscles, and ligaments around the knee and may lead to increased problems with biomechanics and muscular responses. An alternative surgery, the opening wedge osteotomy involves the creation of an opening on the medial side of the tibia which can be distracted slowly over time. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum.