Investigating lipid metabolism and its impact on our immune system

在体内平衡期间，全身免疫反应依赖于血液干细胞的扩张和分化。在对感染的反应中，这些干细胞通过产生先天和适应性免疫细胞来促进快速免疫反应，这些免疫细胞被招募到肝脏和肠道来支持对感染的反应。在感染过程中，造血干细胞需要能量来增殖并分化为免疫细胞，然而这种能量的来源尚不完全清楚。为了更好地了解感染期间血液生产能量需求的调节机制，将使我们能够提出保护和改善全身免疫功能和整体维持全身健康的策略。因此，本项目的目的是确定感染期间造血代谢需求的机制。具体来说，我们将确定各种脂质代谢物和调节剂在这些过程中的作用。

During homeostasis the systemic immune response relies on the expansion and differentiation of blood stem cells. In response to infection, these stem cells promote the rapid immune response by generating innate and adaptive immune cells that are recruited into the liver and the intestine to support the response to infection. During infection the blood stem cells require energy to proliferate and differentiate into immune cells, however were this energy comes from is not fully understood. To gain a better understanding of the mechanisms regulating the energy requierment for blood production during infectoin will enable us to propose strategies to preserve and improve the systemic immune function and to overall maintain whole-body health. Therefore, the aim of this project is to define the mechanisms underpinning metabolic reqyuirement of haematopoiesis during infection. Specifically, we will determine the role of various lipid metabolites and regulators in these processes.