CANDIDA ALBICANS-ASSOCIATED ORAL BIOFILMS

描述(由申请人提供)：本提案寻求在南卡罗来纳医科大学(MUSC)口腔医学院发展南卡罗来纳州口腔健康科布雷的支持。南卡罗来纳州口腔健康科布雷将培训一批有针对性的调查人员，他们将成为成熟的调查人员，并将在牙科医学院口腔和颅面健康研究项目的持续发展方面提供学术领导。该计划高度利用了墨尔本州立大学学术健康科学中心的现有优势，包括：1)由NIH研究所和同行审查赞助商合作并提供充足资金的优秀教师导师库；2)与教师导师小组成员具有牢固的、先前存在的牢固关系的优秀目标调查者库；3)关键的相关研究空间和核心资源；4)接触目前正在接受调查并由MUSC的社区外联计划服务的独特人群；5)获得这些人群的临床材料；6)MUSC和位于马里兰州贝塞斯达的NIH园区的NIDCR内部研究项目之间的创新合作关系，为南卡罗来纳州科布雷口腔健康项目的目标研究人员提供更多的研究指导机会。因此，Cobre资助机制将使牙科医学院能够应用Cobre资源，最有效地实现其研究战略计划的目标，即在MUSC开发一个具有全国竞争力和突出地位的口腔健康研究项目，直接造福于南卡罗来纳州公民的口腔健康需求。南卡罗来纳州科布雷口腔健康计划将：*指导最初的五名有针对性的调查人员，以发展成功的、独立的、由NIH资助的口腔健康科学研究事业。*加强口腔健康研究基础设施。COBRE基金将允许大量开发关键资源(核心)，以开发支持MUSC学术健康科学中心多学科口腔健康研究的研究基础设施。*增聘两名新教员，他们的经验和学科专长将在指导委员会和外部咨询委员会认为至关重要的领域与Cobre调查员的经验和专业知识相辅相成。*在最初的5年奖励之后，维持南卡罗来纳州口腔健康科布雷的基础设施。

DESCRIPTION (provided by applicant): This proposal seeks support for the development of the South Carolina COBRE for Oral Health at the Medical University of South Carolina (MUSC) College of Dental Medicine. The South Carolina COBRE for Oral Health will train a cadre of targeted investigators who will become established investigators and will provide academic leadership in the continued development of the College of Dental Medicine's oral and craniofacial health research program. The program is highly leveraged with existing strengths at MUSC's academic health science center including: 1) a pool of outstanding faculty mentors who are collaborative and well-funded by NIH institutes and peer-review sponsors; 2) a pool of outstanding targeted investigators with strong, pre-existing relationships with members of the faculty mentor group; 3) critical relevant research space and core resources; 4) access to unique populations currently under investigation and served by MUSC's community outreach programs; 5) access to clinical materials from these populations; and 6) an innovative collaborative relationship between MUSC and the NIDCR intramural research program on the NIH campus in Bethesda, MD that provides expanded research mentoring opportunities to targeted investigators in the South Carolina COBRE for Oral Health Program. Thus, the COBRE funding mechanism will allow the College of Dental Medicine to apply COBRE resources to most efficiently meet the goals of its research strategic plan to develop a nationally competitive and prominent oral health research program at MUSC which directly benefits the oral health care needs of the citizens of South Carolina. The South Carolina COBRE for Oral Health program will: * Mentor an initial cadre of five targeted investigators to develop successful, independent, NIH- funded research careers in oral health science. * Enhance the oral health research infrastructure. COBRE funds will permit significantdevelopment of critical resources (cores) in the development of a research infrastructure supportive of multidisciplinary oral health research at MUSC's academic health science center. * Recruit two additional new faculty members whose experience and disciplinary expertise will complement those of the COBRE investigators in areas deemed critical by the Steering and the External Advisory Committees. * Sustain the infrastructure of the South Carolina COBRE for Oral Health beyond the initial 5- year award.