Replacing Aldehydes in Reductive Amination

本项目将从高氧化态羰基衍生物直接开发还原胺化反应。使用高氧化态羰基偶联配偶体进行还原胺化的能力将引入新的化学反应性，打开化学空间，并大大提高这种转化的操作简单性。这一进展的关键是原位生成的醛等价物和参与还原胺化反应。

This project will develop reductive amination directly from high oxidation-state carbonyl derivatives. The ability to perform reductive amination using high oxidation-state carbonyl coupling partners will introduce new chemical reactivity, open chemical space and greatly increase the operational simplicity of this transformation. Key to this advance is the in situ generation of an aldehyde equivalent and the engagement of this in the reductive amination reactions.