LSU DENTAL COBRE: BIOMEDICAL EQUIPMENT CORE

描述(由申请人提供)： 口腔健康通常被认为是整体健康的一面镜子。因此，路易斯安那州立大学健康科学中心最近非常重视与口腔健康相关的研究，作为对这一指控的回应，路易斯安那州立大学牙科学院获得了机构和国家的支持，于2000年建立了口腔和颅面生物学卓越中心。卓越中心内最新出现的研究焦点之一是由几位资深研究人员领导的口腔传染病/发病机制。正在崛起的卓越中心在过去三年中表现出了相当大的生产力，现在正准备通过科布雷来扩大和发展初级教员。为此，我们建议通过结构化的指导计划和有价值的基础和临床研究来培养有前途的初级主要研究人员。主题是“口腔传染病”，包括4个关于口腔健康异常的项目，包括艾滋病毒患者的口腔机会性感染、牙周病和龋齿。指导将通过英才中心和路易斯安那州立大学医学院具有相关专业知识和资助经验的高级调查人员团队进行。此外，重要的基础设施将由三个核心提供，包括行政、生物医学设备和统计。Cobre由一位由NIH资助的知名调查员领导，他在领导中心拨款方面拥有丰富的经验，目前是卓越中心的主任。将通过内部(导师)和外部咨询委员会对基准进行重要的中期和结果评价。COBRE的目标是：(I)通过功勋研究和有组织的指导，将初级教师培养成独立的研究人员；(Ii)提供与口腔健康相关的临床和基础科学研究方面的培训；(Iii)通过指导和招聘，在路易斯安那州立大学牙科学院和英才中心发展口腔健康研究的临界点；(Iv)继续发展/加强现有英才中心的基础设施；以及(V)实施中期和结果评估，以衡量进展情况。长期目标将是在路易斯安那州立大学牙科学院拥有足够数量的经验丰富的独立调查人员，他们的外部资助的研究大大提高了路易斯安那州和全国人民的口腔和一般健康。

DESCRIPTION (provided by applicant): Oral health is often considered a mirror of general health. As such, Louisiana State University Health Sciences Center has recently placed a significant emphasis on oral health-related research, in response to this charge, the LSU School of Dentistry acquired Institutional and State support to establish a Center of Excellence in Oral and Craniofacial Biology in 2000. One of the strongest emerging research foci within the Center of Excellence is oral infectious disease/pathogenesis led by several established senior investigators. The rising Center of Excellence has shown considerable productivity in the past 3 years and is now poised for expansion and development of junior faculty through a COBRE. To this end, we are proposing to develop promising junior principal investigators through a structured mentoring program and meritorious basic and clinical research. The theme is 'Oral Infectious Diseases' and includes 4 projects on oral health anomalies, including oral opportuntistic infections in the HIV patient, periodontal disease, and dental caries. Mentoring will be through teams of senior investigators in the Center of Excellence and LSU School of Medicine with related expertise and funding experience. Moreover, significant infrastructure will be contributed by three Cores, including Administrative, Biomedical Equipment, and Statistics. The COBRE is led by an established NIH-funded Investigator who has extensive experience in leading center grants and is the current Director of the Center of Excellence. There will be significant interim and outcome evaluations of benchmarks through an internal (mentors) and external advisory board. The objectives of the COBRE are to (i) develop junior faculty into independent investigators through meritorious research and structured mentoring, (ii) provide training in clinical and basic science research related to oral health, (iii) develop critical mass in oral health research at the LSU School of Dentistry and Center of Excellence through mentoring and recruitment, (iv) continue to develop/enhance infrastructure of the existing Center of Excellence, and (v) implement both interim and outcome evaluations to measure progress. The long-term goals will be to have a critical mass of experienced independent investigators at the LSU School of Dentistry whose extramurally funded research significantly enhances the oral and general health of persons in the State of Louisiana and nationally.