MT VET COBRE: PROJECT 3, NEUTROPHIL FUNCTION IN ASPERGILLOSIS IMMUNITY

描述(由申请人提供)： 传染病仍然是世界范围内的头号死因和美国的第三大死因。此外，有目的地将高传染性物质释放到环境中已成为国土安全方面令人担忧的一个重要来源。许多对人、牲畜和野生动物的健康很重要的高度传染性疾病都是人畜共患病。Cobre申请的目标是在蒙大拿州立大学建立一个研究中心，该中心将为了解人畜共患病的发病机制做出重大的科学贡献。来自蒙大拿州立大学、蒙大拿大学和美国国立卫生研究院落基山实验室的高级传染病研究人员将构成拟议中心的核心。为了实现这一建议的目标，描述了两个具体目标。第一个目标是增加密歇根州立大学和密歇根大学传染病研究人员的数量，以达到维持一个富有成效和竞争力的研究中心所需的研究人员的临界数量。这一目标将通过两个不同但互补的机制来实现。第一个是通过指导计划和资助他们的研究项目来发展现有的初级教员。第二条途径是在人畜共患疾病研究领域对4名新聘用的终身教职教师提供支持和指导。第二个目标是扩大蒙大拿州传染病研究项目的基础设施，使现有的调查人员和未来的新调查人员能够对人、牲畜和野生动物的高度传染性疾病进行研究。这一目标将首先通过翻新扩大密歇根州立大学有限的BL3设施来实现。翻新后的BL3设施将极大地扩展湿实验室和小动物遏制能力，以及新的大型动物遏制能力。其次，通过购买设备和资助支助人员，将向与拟建中心有关的调查人员提供流式细胞术、基因组学、蛋白质组学和BL3动物控制领域的支助和指导服务。实现这一目标将提供开展人、牲畜和野生动物BL3疾病研究所需的专门和独特的设施，并提供开发免疫疗法研究所需的技术。由于导师的专业知识、密歇根州立大学和密歇根大学杰出的机构支持(1,575,000美元)，以及人畜共患疾病研究的重要性和及时性，我们相信科布雷对这项建议的支持将导致一个将做出重大科学贡献的项目，从而将产生一个可持续和可资助的中心。

DESCRIPTION (provided by applicant): Infectious diseases remain the leading cause of death worldwide and the third leading cause of death in the United States. In addition, purposeful release of highly infectious agents into the environment has become a significant source for concern in regard to homeland security. Many of the highly infectious diseases important to the health of man, livestock, and wildlife, are zoonotic. The goal of this COBRE application is to develop a Center of Research at Montana State University that will make significant scientific contributions to the knowledge of the pathogenesis of zoonotic diseases. Senior infectious disease researchers from Montana State University, University of Montana, and the NIH Rocky Mountain Labs will form the nucleus of the proposed Center. To achieve the goal of this proposal, two specific aims are described. The first aim is to increase the number of infectious disease investigators at MSU and UM in order to achieve the critical mass of researchers necessary to sustain a productive and competitive research center. This aim will be accomplished through two different, but complementary mechanisms. The first will be by the development of current junior faculty through a mentoring program and funding of their research projects. The second pathway will be through the support and mentoring of 4 new tenure track faculty hires in the area of zoonotic disease research. The second aim is to expand the infrastructure of the infectious disease research programs in Montana to make it possible for the current investigators and future new investigators to conduct research on highly infectious diseases of man, livestock, and wildlife. This aim will be accomplished by, firstly, expanding the limited BL3 facility at MSU through renovation. The renovated BL3 facility will have greatly expanded wet lab and small animal containment capability as well as the new capability of large animal containment. Secondly, through the purchase of equipment and funding of support personnel, support and mentoring services in the areas of flow cytometry, genomics, proteomics and BL3 animal containment will be made available to investigators associated with the proposed Center. Accomplishment of this aim will provide the specialized and unique facilities needed to carry out studies of BL3 diseases of man, livestock, and wildlife as well as to provide the technologies needed for research in development of immunotherapies. Because of the expertise of the Mentors, the outstanding MSU and UM Institutional support ($1,575,000), and the significance and timeliness of zoonotic disease research, we believe that COBRE support of this proposal will result in a program that will make significant scientific contributions and will, therefore, result in a sustainable and fundable Center.