COBRE: OK MED RES FOUND: P2: REGULATION OF ANTIBODY PRODUCTION TO A AUTOANTIGEN

描述(由申请人提供)： 这项关于建立生物医学研究卓越中心(Cobre)的建议源于俄克拉荷马医学研究基金会(OMRF)。它包括与俄克拉何马城邻近的俄克拉荷马大学健康科学中心(OUHSC)以及位于俄克拉何马城以南20英里的诺曼市俄克拉荷马大学(UO)主校区的关键合作。科学主题是糖基化在宿主防御中的作用。几乎所有的膜蛋白和分泌蛋白都经历翻译后修饰，特别是糖基化。然而，这些极其不同的修饰的功能仍然知之甚少。俄克拉荷马州在这一领域已经形成了主要优势。该提案旨在通过将糖生物学与心血管生物学、生物工程和免疫学的现有和新兴专业知识相结合来加强这些优势。这种跨学科方法的核心是多产的高级调查人员积极参与指导一群有前途的初级调查人员。新的核心设施将进一步加强他们的研究。这些初级调查人员的成功将扩大重叠科学领域的人才临界质量，这是扩大俄克拉荷马州生物医学研究基础设施的一种协同方法。

DESCRIPTION (provided by applicant): This proposal for a Center for Biomedical Research Excellence (COBRE) originates from the Oklahoma Medical Research Foundation (OMRF). It includes key collaborations with the adjacent University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City and with the main campus of the University of Oklahoma (UO), located 20 miles south of Oklahoma City in Norman. The scientific theme is the role of glycosylation in host defense. Virtually all membrane and secreted proteins undergo post-translational modifications, particularly glycosylation. Yet the functions of these extremely diverse modifications remain poorly understood. Oklahoma has developed major strengths in this area. The proposal aims to build on these strengths by interfacing glycobiology with existing and emerging expertise in cardiovascular biology, bioengineering, and immunology. This interdisciplinary approach centers on active participation of productive, senior investigators in mentoring a group of promising junior investigators. New Core facilities will further enhance their research. The success of these junior investigators will enlarge the critical mass of talent in overlapping scientific areas, a synergistic method to expand the biomedical research infrastructure in Oklahoma.