Alzheimer's Disease Core Center

描述（由申请人提供）：自1990年以来，纽约大学老年痴呆症研究中心一直在为一个全面的、多学科的老年痴呆症研究项目提供核心资源和试点研究支持，该项目涵盖基础研究和社会心理研究。ADCC的主要科学目标是促进和加强将导致早期诊断和预防的研究。在未来5年，核心资源将用于研究从正常衰老到轻度认知障碍（MCI）和早期AD的过渡，以及可能与早期AD重叠的其他痴呆病因。除了纽约大学外，内森克莱恩研究所（NKI）、纽约大学基础研究所（IBR）和纽约市其他机构的研究人员也参与了研究。对AD及相关疾病患者、轻度认知障碍患者和认知正常患者进行纵向尸检研究。在执行委员会和外部科学咨询委员会任职的一名董事和八名副领导监督ADCC。标准ADCC核心支持包括行政，临床，神经病理学，数据管理和教育核心。另外两个重要的资源，神经影像学和护理核心，显著加强了ADCC研究者的研究贡献。临床中心包括脑脊液和血液样本库以及一个卫星多元文化诊所，专注于少数民族招募。神经病理学核心包括IBR的形态测量组件和太阳健康研究所（太阳城，AZ）的卫星。每年，ADC直接支持几项试点研究，并提供核心资源（受试者、临床到广泛的当前研究），这些研究得到NIH和其他来源的主要支持。与其他ADC和国家联盟有广泛的合作，纽约大学ADCC的数据与国家阿尔茨海默病协调中心（NACC）和许多合作研究者共享。NYU ADCC已经并将继续为消除AD问题做出重大贡献。

DESCRIPTION (provided by applicant): Since 1990, the ADCC at NYU has been providing core resources and pilot study support to a comprehensive, multidisciplinary research program on aging and AD that spans basic through psychosocial research. The main scientific goal of the ADCC is to facilitate and enhance research that will lead to early diagnosis and prevention. Over the next 5-years, core resources will be used to study the transition from normal aging to mild cognitive impairment (MCI) and early AD, and also to examine other dementia etiologies that may overlap with early AD. In addition to NYUSM, investigators at the Nathan Kline Institute (NKI), the NYS Institute for Basic Research (IBR), and other New York City area facilities are also participating. Patients with AD and related disorders, subjects with MCI, and cognitively normal subjects are studied longitudinally through postmortem. A Director and eight Associate Leaders who serve on an Executive Committee and an External Scientific Advisory Committee supervise the ADCC. Standard ADCC cores supported consist of Administrative, Clinical, Neuropathology, Data Management and Education Cores. Two additional important resources, Neuroimaging and Caregiver Cores, significantly strengthen the research contributions of the ADCC investigators. The Clinical Core includes CSF and Blood Sample Banks and a Satellite Multicultural Clinic focusing on minority recruitment. The Neuropathology Core includes a morphometry component at IBR and a satellite at the Sun Health Research Institute (Sun City, AZ). Each year, the ADC directly supports several pilot studies, and provides core resources (subjects, clinical to extensive current research receiving primary support from the NIH and other sources. There is extensive collaboration with other ADC's and national consortia, and data from the NYU ADCC is shared with the National Alzheimer's Coordinating Center (NACC) and with numerous collaborating investigators. The NYU ADCC has made and will continue to make substantial contributions toward eliminating the problem of AD.