Alzheimer's Disease Core Center

描述（由申请人提供）：自1990年以来，纽约大学的ADC一直为一个全面的、多学科的老龄化和AD研究项目提供核心资源和支持，该项目涵盖基础研究和社会心理研究。ADC的主要科学目标是促进和加强有助于早期诊断和预防的研究。在未来5年，核心资源将用于研究从正常衰老到轻度认知障碍（MCI）和早期AD的过渡。除了纽约大学管理学院外，内森克莱恩研究所（NKI）、纽约大学基础研究所（IBR）和纽约市其他机构的研究人员也参与了研究。对AD及相关疾病患者、轻度认知障碍患者和认知正常患者进行纵向尸检研究。在执行委员会和外部咨询委员会任职的董事和副领导监督艺发局。支持的标准ADC核心包括行政、临床、神经病理学、数据管理和教育核心。此外，神经影像学和看护者核心显著加强了ADC研究者的研究贡献。临床中心包括一个卫星多元文化项目，重点关注少数民族的招募，以及一个ADC生物库（临床中心、神经影像学中心和神经病理学中心的共同努力），储存并为研究人员提供脑脊液、血液和死后脑组织样本。神经病理学核心包括IBR的形态测量成分。每年，ADC直接支持几项试点研究，并为从NIH和其他来源获得主要支持的广泛当前研究提供核心资源（受试者；临床、神经影像学和社会心理数据；血液、脑脊液和脑组织）。利用ADC的广泛的多学科研究通过创建卓越的脑衰老中心得到了加强。与其他ADC和国家联盟也有广泛的合作，纽约大学ADC的数据与国家阿尔茨海默病协调中心（NACC）和许多合作研究者共享。ADC已经并将继续为消除AD问题做出重大贡献。

DESCRIPTION (provided by applicant): Since 1990, the ADC at NYU has been providing core resources and support to a comprehensive, multidisciplinary research program on aging and AD that spans basic through psychosocial research. The main scientific goal of the ADC is to facilitate and enhance research that will lead to early diagnosis and prevention. Over the next 5-years, core resources will be used to study the transition from normal aging to mild cognitive impairment (MCI) and early AD. In addition to NYU SoM, investigators at the Nathan Kline Institute (NKI), the NYS Institute for Basic Research (IBR), and other New York City area facilities are also participating. Patients with AD and related disorders, subjects with MCI, and cognitively normal subjects are studied longitudinally through postmortem. A Director and Associate Leaders who serve on an Executive Committee and an External Advisory Committee supervise the ADC. Standard ADC cores supported consist of Administrative, Clinical, Neuropathology, Data Management and Education Cores. In addition, Neuroimaging and Caregiver Cores significantly strengthen the research contributions of ADC investigators. The Clinical Core includes a Satellite Multicultural Program focusing on minority recruitment, and an ADC Biorepository (a joint effort of the Clinical, Neuroimaging and Neuropathology Cores) stores and provides investigators with CSF, blood and postmortem brain tissue samples. The Neuropathology Core includes a morphometry component at IBR. Each year, the ADC directly supports several pilot studies, and provides core resources (subjects; clinical, neuroimaging and psychosocial data; blood, CSF and brain tissue) to extensive current research receiving primary support from NIH and other sources. The extensive multidisciplinary research utilizing the ADC has been strengthened by the creation of a Center of Excellence on Brain Aging. There is also extensive collaboration with other ADC's and national consortia, and data from the NYU ADC is shared with the National Alzheimer's Coordinating Center (NACC) and with numerous collaborating investigators. The ADC has made and will continue to make substantial contributions toward eliminating the problem of AD.