Alzheimer's Disease Core Center

描述（由申请人提供）：自1990年以来，ADC在纽约大学一直提供核心资源和支持，以全面的，多学科的研究计划，对老龄化和AD，跨越基本通过心理社会研究。ADC的主要科学目标是促进和加强研究，从而导致早期诊断和预防。在接下来的5年里，核心资源将用于研究从正常衰老到轻度认知障碍（MCI）和早期AD的转变。除了纽约大学SoM，Nathan Kline研究所（NKI），纽约州基础研究所（IBR）和其他纽约市地区设施的研究人员也参与其中。AD及相关疾病患者、MCI受试者和认知正常受试者通过尸检进行纵向研究。一名主任和助理领导人谁担任执行委员会和外部咨询委员会监督ADC。支持的标准ADC核心包括行政、临床、神经病理学、数据管理和教育核心。此外，Neuroimaging和Caregiver Cores显著加强了ADC研究人员的研究贡献。临床核心包括一个专注于少数民族招募的卫星多元文化计划，以及一个ADC生物储存库（临床，神经影像和神经病理学核心的共同努力），储存并为研究人员提供CSF，血液和死后脑组织样本。神经病理学核心包括IBR的形态测量学组件。每年，ADC直接支持几个试点研究，并提供核心资源（受试者;临床，神经影像学和心理社会数据;血液，CSF和脑组织），以广泛的当前研究接受NIH和其他来源的主要支持。利用ADC进行的广泛的多学科研究通过创建脑老化卓越中心得到了加强。与其他ADC和国家联盟也有广泛的合作，来自纽约大学ADC的数据与国家阿尔茨海默病协调中心（NACC）和许多合作研究人员共享。香港艺术发展局一直致力消除阿尔茨海默病，并会继续作出重大贡献。

DESCRIPTION (provided by applicant): Since 1990, the ADC at NYU has been providing core resources and support to a comprehensive, multidisciplinary research program on aging and AD that spans basic through psychosocial research. The main scientific goal of the ADC is to facilitate and enhance research that will lead to early diagnosis and prevention. Over the next 5-years, core resources will be used to study the transition from normal aging to mild cognitive impairment (MCI) and early AD. In addition to NYU SoM, investigators at the Nathan Kline Institute (NKI), the NYS Institute for Basic Research (IBR), and other New York City area facilities are also participating. Patients with AD and related disorders, subjects with MCI, and cognitively normal subjects are studied longitudinally through postmortem. A Director and Associate Leaders who serve on an Executive Committee and an External Advisory Committee supervise the ADC. Standard ADC cores supported consist of Administrative, Clinical, Neuropathology, Data Management and Education Cores. In addition, Neuroimaging and Caregiver Cores significantly strengthen the research contributions of ADC investigators. The Clinical Core includes a Satellite Multicultural Program focusing on minority recruitment, and an ADC Biorepository (a joint effort of the Clinical, Neuroimaging and Neuropathology Cores) stores and provides investigators with CSF, blood and postmortem brain tissue samples. The Neuropathology Core includes a morphometry component at IBR. Each year, the ADC directly supports several pilot studies, and provides core resources (subjects; clinical, neuroimaging and psychosocial data; blood, CSF and brain tissue) to extensive current research receiving primary support from NIH and other sources. The extensive multidisciplinary research utilizing the ADC has been strengthened by the creation of a Center of Excellence on Brain Aging. There is also extensive collaboration with other ADC's and national consortia, and data from the NYU ADC is shared with the National Alzheimer's Coordinating Center (NACC) and with numerous collaborating investigators. The ADC has made and will continue to make substantial contributions toward eliminating the problem of AD.