Organic Synthesis Reagents on Transition Metals

描述（由申请人提供）：复杂分子中碳-碳键的合成对于构建新药剂至关重要。在过去的几年中，烯烃复分解已经成为用于构建此类化合物的新的通用方法。这一转变的关键是活性、高效和选择性催化剂的可用性。在过去的几年中，已经开发了一系列催化剂，其在广泛的未保护的官能团存在下显示出高活性。进一步的应用将需要对映体和立体选择性的催化剂，并且将对高度官能化的烯烃进行复分解。在上一个赠款期间，在开发直接配体设计的模型方面取得了进展。在下一个授权期间，该模型将用于构建新的配体系统，用于对映选择性交叉复分解，用于交叉复分解中的立体选择性（控制形成的双键的E：Z比），并增加空间位阻烯烃的反应性。将制备各种新的N-杂环卡宾配体，其不仅在选择性烯烃复分解催化剂的制备中具有应用，而且在催化剂设计中具有普遍用途。此类催化剂的成功构建将为生物活性分子的构建开辟有效的新途径。

DESCRIPTION (provided by applicant): The synthesis of carbon-carbon bonds in complex molecules is essential for the construction of new pharmaceutical agents. Over the past several years, olefin metathesis has become a new general method for the construction of such compounds. Key to this transformation is the availability of catalysts that are active, efficient and selective. Over the past several years, a family of catalysts has been developed that shows high activity in the presence of a wide array of unprotected functional groups. Further applications will require catalysts that are enantio and stereoselective and will carry out metathesis on highly functionalized olefins. During the last granting period, progress was made in the development of a model to direct ligand design. During the next granting period, this model will be used to construct new ligand systems for enantioselective cross metathesis, for the stereoselective (control the E:Z ratio of the double bonds formed) in cross metathesis and increase the reactivity of sterically hindered olefins. A variety of new N-heterocyclic carbene ligands will be prepared that will not only have applications in the preparation of selective olefin metathesis catalysts but will be of general use in catalyst design. Successful construction of such catalysts will open efficient new routes to the construction of bioactive molecules.