ALZHEIMER'S DISEASE RESEARCH CENTER

这是杜克大学医学中心约瑟夫和凯瑟琳·布莱恩阿尔茨海默病研究中心（布莱恩ADRC）的第三次更新。布赖恩ADRC是一个多学科的研究中心，支持和进行阿尔茨海默病（AD）和相关疾病的基础科学和临床研究，重点是遗传易感性，早期诊断，尸检确认和教育推广。努力包括布赖恩ADRC的具体目标是：（1）提供诊断，预防和治疗痴呆症的专业知识;（2）提供结构和背景的确认，评估，纵向跟踪和研究参与的大型AD家庭;（3）传播组织，并提供必要的资源进行研究;（4）促进AD和相关疾病的临床研究，以及（5）进行导致AD生物学进步的研究。该中心的结构包括核心：行政; -临床研究开发;神经病理学;教育和信息研究培训;和研究项目; - ApoE保持血脑屏障完整性，-胆固醇对人类ApoE和APP相互作用的影响，AD中的氧化应激;和每年两个试点项目（每年确定）。该中心整合协调，并促进建立和发展研究人员的跨学科合作。它提供了重要的资源，例如，特征明确的患者和对照受试者、家族信息、组织和生物标本。这些资源加强了独立和合作的研究工作，增加了疾病。最终目标是为疾病受害者及其家属制定预防、护理和治疗战略，并全面改善保健服务。

This is the third renewal of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC) at Duke University Medical Center. The Bryan ADRC is a multi-disciplinary research center that supports and conducts basic science and clinical research in Alzheimer's disease (AD) and related disorders with an emphasis on genetic predisposition, early diagnosis, autopsy confirmation, and educational outreach. Efforts include specific aims of the Bryan ADRC are to: (1) provide expertise for the diagnosis, prevention, and treatment of dementing illnesses; (2) provide the structure and context for the ascertainment, evaluation, longitudinal follow-up and research participation of large AD families; (3) disseminate tissue and provide needed resources for research; (4) facilitate clinical research studies in AD and related disorders, and (5) perform research leading to advances in the biology of AD. The Center's structure consist of Cores: Administrative; -Clinical Research Development; Neuropathology; Education and Information Research Training; and research projects; - ApoE Maintains Blood Brain Barrier Integrity, -Cholesterol Effects on Human ApoE and APP Interactions, Oxidative Stress in AD; and two pilot projects per year (determined yearly). The Center integrates coordinates, and foster interdisciplinary collaborations of established and developing investigators. It provides important resources, e.g., well- characterized patients and control subjects, family information, tissue and biological specimens. These resources strengthen independent and collaborative research efforts, increase illnesses. The ultimate goals to be obtained are the development of prevention, care, and treatment strategies for disease victims and their families and the overall improvement of health care delivery.