Impact of pregnancy-specific glycoproteins on development and ageing

我们的目标是研究遗传变异如何影响PSG基因调控，从而影响滋养层细胞和衰老细胞的细胞表型。我们将利用先进的干细胞和测序技术与表观基因组学和功能分析相结合，汇集滋养层基因调控(Branco实验室)、群体基因组学/表观基因组学(Bell实验室)和老龄化(Altos实验室)方面的专业知识。更具体地说，我们的目标是：1.深入研究一组诱导多能干细胞(IPSC)系上PSG基因座的遗传学特征。检测PSG基因变异对IPSC来源的滋养层细胞的影响。检测PSG基因变异对IPSC细胞衰老模型的影响

We aim to investigate how genetic variation impacts PSG gene regulation and consequently on cellular phenotypes in trophoblast and senescent cells. We will leverage cutting-edge stem cell and sequencing technologies with epigenomics and functional assays, bringing together expertise in trophoblast gene regulation (Branco lab), population genomics/epigenomics (Bell lab) and ageing (Altos Labs). More specifically, we aim to:1. Deeply characterise the genetics of the PSG locus on a set of induced pluripotent stem cell (iPSC) lines.2. Test the impact of PSG genetic variation on iPSC-derived trophoblast cells.3. Test the impact of PSG genetic variation on iPSC-derived cellular models of senescence