HIV immune environment impact on pre-eclampsia
HIV免疫环境对先兆子痫的影响
基本信息
- 批准号:10548583
- 负责人:
- 金额:$ 8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAfrica South of the SaharaAngiogenic FactorArteriesAspirinAuthorization documentationCellsCessation of lifeClinicalCohort StudiesConceptionsControl GroupsDevelopmentDiseaseDoseEclampsiaEffectivenessEnvironmentEtiologyExclusion CriteriaFlow CytometryFunctional disorderFundingGene Expression ProfileGenetic Predisposition to DiseaseHIVHIV InfectionsHemorrhageHepaticHypertensionImmuneImmune systemImmunologicsImmunosuppressionImpairmentIncidenceInflammatoryInternational Maternal Pediatric Adolescent AIDS Clinical TrialsInterventionInvadedKidneyKnowledgeLeadLeadershipMaternal HealthMaternal MortalityMorbidity - disease rateMothersNatural Killer CellsOrganOxidative StressP-SelectinPGF genePerfusionPeripheral Blood Mononuclear CellPhenotypePilot ProjectsPlacentationPlayPre-EclampsiaPredisposing FactorPregnancyPregnancy ComplicationsPregnant WomenProphylactic treatmentProteinuriaRecommendationReportingResidual stateResourcesRestRiskRisk FactorsRoleRuptureSafetySamplingSampling StudiesSecond Pregnancy TrimesterSpecific qualifier valueSpecimenSymptomsT-LymphocyteTestingThird Pregnancy TrimesterTimeVertical Disease TransmissionVulnerable PopulationsWomanantiretroviral therapychemokinecohortcytokinedesignendothelial dysfunctionexhaustionfetalhigh riskimmune activationinflammatory markermaternal morbiditymortalitypre-clinicaltranscriptome sequencingtranscriptomicstrophoblast
项目摘要
PROJECT SUMMARY/ABSTRACT
Pre-eclampsia (PE) is a leading cause of maternal and fetal morbidity and mortality. It is a placental-driven
disease characterized by alterations in placental development and placental perfusion that lead to the clinical
stage of placental oxidative stress, hypertension and proteinuria. The exact etiology of PE is still unknown.
However, a growing body of evidence suggests that immune imbalances during placentation may drive the
development of the disease. In particular, PE seems to be characterized by a lack of Th1/Th2 switch early after
conception and an altered immune and angiogenic environment with higher levels of inflammatory markers and
lower levels of tolerogenic markers. Moreover, impaired phenotype and function of decidual NK cells, which play
a critical role in placentation, are probably involved interfering with correct trophoblast invasion. HIV infection in
untreated pregnant women appears to drive lower rates of PE development. This may be due to HIV-driven
immune suppression. However, HIV infected women treated with combination antiretroviral therapy (cART) may
be at higher risk of PE than untreated women or uninfected controls. The exact impact of cART on the
development of PE is still unclear. However, studies that distinguish cART at conception from cART started
during the 2nd or 3rd trimester report higher incidence of PE in women treated with cART at conception. Herein
we will test the hypothesis that immune imbalances in HIV infected pregnant women treated with cART at
conception predispose to the development of PE. We will test our hypothesis investigating samples collected
from a large, concluded IMPAACT study, P1025. The P1025 study samples will allow for the comparison of 2nd
and early 3rd trimester women on cART at conception with HIV infected women who started cART during the 2nd
trimester. Our two specific aims focus on: SA1) determining the association of cART at conception with known
angiogenic and inflammatory markers of PE and, SA2) investigating if and how immune cell markers on T cell
and NK cell subsets correlate with angiogenic markers that are known to predict the development of PE in women
on cART at conception. In conclusion, we are addressing a critical problem in maternal health in HIV infected
women that could help to identify and test new strategies to reduce the development of PE in cART-treated HIV
infected pregnant women.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elena Martinelli其他文献
Elena Martinelli的其他文献
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{{ truncateString('Elena Martinelli', 18)}}的其他基金
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关闭艾滋病毒白噪声:从长寿命库切换到短寿命库
- 批准号:
10676478 - 财政年份:2023
- 资助金额:
$ 8万 - 项目类别:
Exploration into the Forgotten HIV Reservoir with Models of HIV/SIV Persistence in Mucosal Tissues
利用粘膜组织中 HIV/SIV 持续存在的模型探索被遗忘的 HIV 病毒库
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10460078 - 财政年份:2022
- 资助金额:
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- 资助金额:
$ 8万 - 项目类别:
Role of integrins in HIV/SIV transmission across cervico-vaginal mucosa
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- 批准号:
8440738 - 财政年份:2012
- 资助金额:
$ 8万 - 项目类别:
Role of integrins in HIV/SIV transmission across cervico-vaginal mucosa
整合素在 HIV/SIV 宫颈阴道粘膜传播中的作用
- 批准号:
8263136 - 财政年份:2012
- 资助金额:
$ 8万 - 项目类别:
Role of integrins in HIV/SIV transmission across cervico-vaginal mucosa
整合素在 HIV/SIV 宫颈阴道粘膜传播中的作用
- 批准号:
8610236 - 财政年份:2012
- 资助金额:
$ 8万 - 项目类别:
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