2nd International Pathogenesis of Rare Neuroimmunologic Disorders

神经免疫学疾病是一组定义松散的疾病，其中有一种免疫调节 神经系统损伤包括：多发性肌炎、重症肌无力(MG)、 炎症性多发性神经病、横贯性脊髓炎、HTLV-1相关性脊髓病、僵硬综合征 (SPS)、视神经脊髓炎(NMO)、视神经炎(ON)、多发性硬化(MS)、急性播散性疾病 脑脊髓炎(ADEM)，桥本？S脑炎，拉斯穆森？S脑炎，副肿瘤 与链球菌相关的脑脊髓炎(PE)和儿童自身免疫性神经精神疾病 感染(熊猫)。这份名单还包括结节病的神经学表现，肖格伦？S 综合征、感染(即JC病毒、脑膜炎和艾滋病毒)和操纵免疫系统的反应 (免疫重建综合征)。尽管每种疾病都是独一无二的，但它们都有共同的免疫致病因素 他们中的许多人之间的机制证明了他们作为单一光谱上的实体进行研究的合理性。进一步探索 为了继续在2004年的一次类似研讨会上建立的合作，我们组织了2 第二名 罕见神经免疫性疾病的国际？发病机制？工作坊将于#年在喜来登酒店举行 巴尔的摩医学博士，2006年7月20日至22日。研讨会将不以疾病为导向，而是以机制为导向 以此为导向，并将涉及许多神经免疫学疾病的讨论，因为它们与 神经系统中的自身免疫力。 这次研讨会的重点是罕见的神经免疫学疾病，而不是 然而，与会者将被邀请讨论进展情况 特别是在多发性硬化症方面，这些进展为其他神经免疫紊乱的研究提供了信息和教育。 与会者将探讨以下共同主题：遗传学和触发机制；体液 对自身免疫的贡献；细胞对自身免疫的贡献；免疫细胞的迁移；先天免疫 贡献；神经保护；神经免疫串扰；重新髓鞘形成；新的成像和新兴 免疫疗法。参与者将了解到这些障碍的相似之处，并因此从相似中受益 治疗方法；以及在它们不同的地方，阐明需要独特的治疗策略。这个 研讨会的中心前提是通过讨论一组独特的和共同的病理过程 罕见疾病，参与者将激发新的、合作的研究，这是推进所需的 对这些障碍的理解。工作坊规模小，互动性强，有别于其他 更大的研讨会，通常强调更常见的神经免疫疾病(特别是多发性 硬化症)，很大程度上是说教性质的。研讨会将征集高年级和低年级学生参加。 科学家/学生，以刺激对这些障碍的长期研究。诉讼程序将是 在医学文献中传播。

Neuroimmunologic disorders are a loosely defined group of disorders in which there is an immunemediated injury of the nervous system that include the following: polymyositis, myasthenia gravis (MG), inflammatory polyneuropathies, transverse myelitis, HTLV-1 associated myelopathy, stiff person syndrome (SPS), neuromyelitis optica (NMO), optic neuritis (ON), multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), Hashimoto?s encephalitis, Rasmussen?s encephalitis, paraneoplastic encephalomyelitis (PE), and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Also included in this list are neurologic manifestations of sarcoidosis, Sjogren?s syndrome, infections (i.e. JC virus, meningitis and HIV) and responses of manipulating the immune system (immune reconstitution syndrome). Though each disorder is unique, there are shared immunopathogenic mechanisms among many of them that justify their study as entities on a single spectrum. To further explore this and to continue the collaborations forged at a similar symposium in 2004, we have organized the 2 2nd nd international ?Pathogenesis of Rare Neuroimmunologic Disorders? workshop to be held at the Sheraton in Baltimore MD from July 20th-22nd, 2006. The workshop will not be disease oriented, but rather, mechanism oriented, and will involve discussions of many neuroimmunologic disorders as they pertain to mechanisms of autoimmunity in the nervous system. This workshop will focus on rare neuroimmunologic disorders, rather than on the most common disease in this group, MS. However, participants will be invited to discuss advances in MS specifically as these advances inform and educate research in other neuroimmunologic disorders. Participants will explore the following common themes: Genetics and triggering mechanisms; humoral contributions to autoimmunity; cellular contributions to autoimmunity, migration of immune cells; innate immune contributions; neuroprotection; neural-immune cross talk; remyelination; novel imaging and emerging immunotherapies. Participants will learn where the disorders are similar and therefore benefit from similar therapeutic approaches; and where they are distinct, elucidating the need for unique treatment strategies. The central premise of the symposium is that by discussing unique and shared pathologic processes of a group of rare disorders, participants will stimulate novel, collaborative investigations necessary to advance understanding of these disorders. The workshop will be small and interactive, distinguishing it from other larger symposia which typically emphasize the more common neuroimmunologic disorders (especially multiple sclerosis) and are largely didactic. The workshop will solicit participation from both senior and junior scientists/students in order to stimulate long-term research in these disorders. The proceedings will be disseminated in the medical literature.