Pathogenesis of Rare Neuroimmunologic Disorders

描述(由申请人提供)：神经免疫学疾病是一组定义不严格的疾病，其中有免疫介导的神经系统损伤。有多种罕见的神经免疫疾病：多发性肌炎、重症肌无力、CIDP、横贯性脊髓炎、TSP/HAM、僵硬综合征、视神经脊髓炎、视神经炎、ADEM、熊猫、桥本脑炎、拉斯穆森脑炎和副肿瘤性脑脊髓炎(PE)。虽然每种疾病都是独一无二的，但最近的发现表明，其中许多疾病之间存在共同的免疫致病机制。为了进一步探讨这一问题，我们组织了一次国际会议，名为“罕见神经免疫紊乱的发病机制研讨会”，将在巴尔的摩凯悦酒店举行。医学博士，2004年8月19日-20日。本次研讨会的与会者将探讨四个共同主题：免疫耐受崩溃的触发机制；体液免疫效应机制；细胞免疫效应机制；以及神经损伤的途径。我们将了解疾病在哪里相似，因此从相似的治疗方法中受益；在哪里，它们是不同的，阐明独特治疗策略的必要性。研讨会的中心前提是，通过讨论一组罕见疾病的独特和共同的病理过程，我们将激发必要的新的、合作的研究，以促进对这些疾病的了解。研讨会将是一个小型的互动研讨会，区别于其他更大的研讨会，后者通常强调更常见的神经免疫疾病(特别是多发性硬化症)，并主要是说教性质的。我们将征集资深和初级科学家/学生的参与，以促进对这些障碍的长期研究。这些病历将在医学文献中传播。我们相信，这次研讨会将在促进我们对疾病的理解方面发挥关键作用，这些疾病在病理生理上是相关的，但由于它们的罕见，人们对它们的了解很少。

DESCRIPTION (provided by applicant): Neuroimmunologic disorders are a loosely defined group of disorders in which there is an immune-mediated injury of the nervous system. There are a variety of rare neuroimmunologic disorders: polymyositis, myasthenia gravis, CIDP, transverse myelitis, TSP/HAM, stiff person syndrome, neuromyelitis optica, optic neuritis, ADEM, PANDAS, Hashimoto's encephalitis, Rasmussen's encephalitis, and paraneoplastic encephalomyelitis (PE). Though each disorder is unique, recent findings have suggested that there are shared immunopathogenic mechanisms among many of them. To further explore this, we have organized an international meeting, "Pathogenesis of Rare Neuroimmunologic Disorders Workshop" to be held at the Hyatt Regency in Baltimore. MD on August 19th-20th, 2004. Participants at this workshop will explore four common themes: Triggering mechanisms in breakdown of immune tolerance; humoral immune effector mechanisms; cellular immune effector mechanisms; and pathways of neural injury. We will learn where the disorders are similar and therefore benefit from similar therapeutic approaches; and where they are distinct, elucidating the need for unique treatment strategies. The central premise of the workshop is that by discussing unique and shared pathologic processes of a group of rare disorders, we will stimulate novel, collaborative investigations necessary to advance understanding of these disorders. The workshop will be a small interactive one, distinguishing it from other larger symposia which typically emphasize the more common neuroimmunologic disorders (especially multiple sclerosis) and are largely didactic. We will solicit participation from both senior and junior scientists/students in order to stimulate long-term research in these disorders. The proceedings will be disseminated in the medical literature. We believe this workshop will serve a critical role in advancing our understanding of disorders that are pathophysiologically linked yet, because of their rarity, are poorly understood.