Rapid Kinetic and Thermodynamic Determination Using Automated Flow

该项目是开发用于制药行业的自动化流程开发平台的团队的一部分。这项工作将解决多相（气-液-固）连续流动化学反应的监测、控制和自我优化，使用新的反应量热法和光谱方法进行快速动力学和热力学测定。实验数据将与新的预测硅片方法结合使用，以促进改进工艺开发，帮助降低成本，浪费，提高生产率和质量。该项目涉及阿斯利康过程开发部门，将培养化学和过程工程界面所需技能的高素质学生，化学生产部门越来越需要这些技能。

This project forms part of a team developing an automated process development platform for use in the pharma industry. The work will address the monitoring, control, and self-optimisation of multiphasic (gas-liquid-solid) continuous flow chemical reactions, using novel reaction calorimetry and spectroscopic methods for rapid kinetic and thermodynamic determination. The experimental data will be used in combination with new predictive, in-silico, methods to facilitate improved process development, helping reduce cost, waste, and improve productivity and quality. The project involves AstraZeneca Process Development Department and will train a high calibre student in skills needed at the chemistry and process engineering interface that are increasingly sought by the chemical producing sector.