Cell Signalling

细胞信号传导效应在广泛的生物过程中发挥着至关重要的作用，例如控制细菌感染的毒力或确定许多疾病的治疗效果。此外，它们的作用范围很广，从亚细胞（例如确定特定药物如何影响特定类型的细胞）到器官或群体（例如通过群体感应系统，许多细菌通过该系统确定是否具有毒性）。因此，迫切需要对这些高度复杂的系统进行更多的定量理解，这些系统非常适合数学研究。研究非线性动力系统的经验将为这样的项目提供有益的背景。

Cell signalling effects have crucial roles to play in a vast range of biological processes, such as in controlling the virulence of bacterial infections or in determining the efficacy of treatments of many diseases. Moreover, they operate over a wide range of scales, from subcellular (e.g. in determining how a particular drug affects a specific type of cell) to organ or population (such as through the quorum sensing systems by which many bacteria determine whether or not to become virulent). There is therefore an urgent need to gain greater quantitative understanding of these highly complex systems, which are well-suited to mathematical study. Experience with the study of nonlinear dynamical systems would provide helpful background for such a project.