Exploring the role of RuBisCo binding domains in algal carbon fixation

Rubisco是地球上最重要的蛋白质之一，在植物和藻类中催化二氧化碳固定转化的第一步。如果我们要利用这种酶来对抗气候变化和食物短缺，了解Rubisco的生物化学是必不可少的。因此，在这个高度跨学科的项目中，我们将利用我们在合成化学和化学生物学方面的专业知识，对Rubisco生物化学目前知之甚少的一个方面获得前所未有的理解——物理化学上保守的，但无序的结合域在控制Rubisco组装中的作用。

Rubisco is one of the most important proteins on the planet, catalysing the first step in the conversion of carbon dioxide fixation in plants and algae. Understanding the biochemistry of Rubisco is essential if we are to harness this enzyme in the fight against climate change and food shortage. In this highly interdisciplinary project, we will therefore exploit our expertise in synthetic chemistry and chemical biology to gain unprecedented understanding of a currently poorly understood aspect of Rubisco biochemistry - the role of physicochemically conserved, yet disordered binding domains in controlling Rubisco assembly.