Improving outcomes in opiate dependence by understanding barriers and facilitators to opiate detoxification.

2021年，英国大约一半的药物中毒死亡与鸦片剂有关，这是有记录以来的最高数字。随着阿片类药物完全戒毒（即减少剂量和停止使用）的减少，迫切需要新的药物来支持戒断。这一领域的研究资金不足且被忽视。帝国理工学院的成瘾小组是英国唯一一个研究治疗阿片类药物依赖的新药理靶点的小组。forward研究旨在调查巴氯芬支持美沙酮解毒的安全性和有效性。为了了解和优化新疗法的实施，首先了解为什么完成戒毒的人数在下降，参与者恢复的动机，以及戒断的潜在障碍是至关重要的。我的项目旨在确定阿片类药物成瘾治疗的关键促进因素和障碍。它将使用混合方法，分析来自问卷调查、半结构化访谈和当前文献的数据。它希望这项研究能够提供一个理解，为什么完成排毒的人数在下降，以及可以做些什么来支持那些希望排毒的人，或者如果禁欲可能会改善他们的健康。研究结果将通过帮助解释疗效数据为试验增加巨大价值，并可嵌入未来的临床和研究实践中

In 2021, approximately half of all drug poisoning mortalities in England involved an opiate, the highest number since records began. With a decline in completed opioid detoxes (i.e. dose reduction and cessation of use),the need for new medications to support abstinence isurgent. Research in this area is underfunded and neglected.The addiction team at Imperial College is the only group in the UK conducting research into new pharmacological targets for the treatment of opioid dependence. The FORWARDS study aims to investigate the safety andefficacy of baclofen to support detoxification from methadone. To inform and optimise the implementation of novel treatments, it is crucial to first understand why the number of completed detoxes is declining, participantmotivations for recovery, and potential barriers to abstinence.My project aims to identify key facilitators and barriers to the treatment of opioid addiction. It would use a mixed-method approach, analysing data from questionnaires, semi-structured interviews, and current literature. It ishoped the study would offer an understanding as to why the number of completed detoxes is declining, and what can be done to support those wishing to detox or whose health may improve if abstinent. Findings would add hugevalue to the trial by aiding the interpretation of efficacy data, and can be embedded into future clinical and research practice