Bone Sparing Effects of Soy Phytoestrogens in Menopause

女性一生中有三分之一的时间处于更年期。长期雌激素缺乏的并发症 在绝经期的几年里，这是很好的。虽然激素替代疗法（HRT）可以节省 妇女的一些并发症，妇女健康倡议的调查结果表明， 健康风险，促使越来越多的妇女从处方HRT转向非处方HRT的风险 希望大豆植物雌激素和其他天然来源的“雌激素”可以取代 处方雌激素的好处，同时节省关键的副作用。尽管有相当广泛的 现在植物雌激素的使用迅速增长，主要差距仍然是我们对它们的长期认识， 有效性和安全性。我们建议进行“大豆植物雌激素替代雌激素（SPARE）” 在年轻绝经期妇女中进行的一项研究，旨在评估使用纯化大豆治疗2年的有效性 预防骨质流失。我们的研究还将探讨口服维生素E的有效性， 预防更年期症状和其他与雌激素缺乏相关的变化。这项研究将 描述大豆异黄酮的特定制剂在人体中的作用，并将这些作用与 与主要代谢物的循环血清水平，提供了新的见解，他们的长期- 术语生物学行为。这项为期5年的研究将提供一个知识基础， 妇女可以开始对HRT和绝经期体征和症状做出更明智的决定。

Women will live a third of their lives in menopause. The complications of prolonged estrogen deficiency during the menopausal years are well established. Although hormone replacement therapy (HRT) can spare women some of these complications, the Women's Health Initiative findings indicate significant potential health risks, risks that prompt more and more women to turn from prescribed HRT to over-the-counter products in the hope that soy phytoestrogens and other "estrogens" from natural sources can replace prescription estrogens in terms of benefits while sparing critical side effects. In spite of the fairly widespread and now rapidly growing use o f phyto estrogens, maj or gap s remain in our knowledge o f their long-term efficacy and safety. We propose to conduct a "Soy Phytoestrogens As Replacement Estrogen (SPARE)" study in young menopausal women to evaluate the effectiveness of a 2-year treatment with purified soy isoflavones in preventing bone loss. Our study will also explore the effectiveness of oral isoflavones in preventing menopausal symptoms and other changes associated with estrogen deficiency. The study will characterize the actions of a defined preparation of soy isoflavones in humans and will correlate these actions with the circulating serum levels of the principal isoflavone metabolites, providing new insights on their long- term biological actions. This 5-year study will provide a foundation of knowledge from which menopausal women can begin to make more informed decisions regarding HRT and menopausal signs and symptoms.