MRI Biometry of the Pseudophakic Cadaver Eye

描述(由申请人提供)：老花眼是随着年龄的增长而丧失的住宿能力，业界正在积极努力为老花眼提供手术矫正，因为这种产品的潜在市场是巨大的。策略包括晶状体填充、巩膜治疗，以及最值得注意的是发展可调节人工晶状体(IOL)。然而，尽管人们对人工晶状体矫正老花眼(以及近视、远视和散光)重新产生了兴趣，但结果一直令人失望，许多问题仍然存在，包括光学和触觉的大小和术后位置的稳定性，Soemmering环和后囊混浊(PCO)的发展，功率计算，以及这些甚至是现有的IOL设计的不良影响。PI开发的高分辨率MRI技术不受虹膜的阻碍，因此能够提供整个IOL(光学和触觉)及其与周围眼内结构的几何关系的非侵入性原位可视化；这种信息是任何其他方法无法获得的。这项研究的最终目标是建立一个生物测量学数据库，从有晶状体和人工晶状体眼球的MRI图像中获得独特的信息，以便充分描述IOL在前段的放置情况，并在现有的在体MRI生物测量和身体生物测量之间提供急需的校准算法，因为身体研究通常用于IOL设计。此外，后囊混浊是白内障手术中一种常见的降低视力的并发症，与人工晶状体的倾斜和偏心有关，特别是在新的人工晶状体设计中。Soemmering环几乎在每一次人工晶状体植入后发育，是后囊混浊的直接前驱，与包括瞳孔阻滞性青光眼在内的其他并发症有关，我们的初步数据表明，它也与人工晶状体错位密切相关。我们计划建立无创性的体外MRI分级Soemmering环的方法，并将人工晶状体眼球的Soemmering环与眼前段生物测量和IOL的类型、位置、倾斜度和偏心相关联。该项目的成功完成将有助于建立模型，使更好的人工晶状体、有晶状体和调节人工晶状体设计以及其他矫正老花眼的方法得到模拟和开发。此外，它还将有助于构建术前人工晶状体功率计算的精细算法，并提高我们对人工晶状体手术后并发症的理解。白内障手术是一种常见的手术，其结果是摘除人类晶状体并将其替换为人工晶状体(IOL)。这是一种安全的手术，但也会出现并发症。人们正在设计许多新的人工晶状体，以进一步提高白内障手术后的视力；然而，人们对这些新设计的安全性和有效性存在担忧。磁共振成像具有完全显示完整眼内人工晶状体位置的独特能力，将被用于研究带人工晶状体的身体球镜，以便更好地了解人工晶状体植入后可能发生的并发症，并允许设计出更好、更安全的人工晶状体。

DESCRIPTION (provided by applicant): Presbyopia is the loss of accommodation with age and industry efforts to provide surgical correction for presbyopia are vigorously underway as the potential market for such a product is substantial. Strategies include lens refilling, scleral treatments, and, most notably, the development of accommodating intraocular lenses (IOLs). However, despite this renewed interest in IOLs for the correction of presbyopia (as well as myopia, hyperopia, and astigmatism), results have been disappointing and many questions remain regarding the optic and haptic sizing and post-operative positional stability, development of Soemmering's ring and posterior capsule opacification (PCO), power calculations, and adverse effects of these and even established IOL designs. The high-resolution MRI techniques developed by the PI are not hampered by the iris and are thus able to provide non-invasive in-situ visualization of the entire IOL (optic and haptics) and its geometric relationship to surrounding intraocular structures; this information cannot be obtained by any other method. The ultimate goal of this study is to produce a biometric database of the unique information obtained from MRI images of both phakic and pseudophakic cadaver globes in order to fully characterize IOL placement in the anterior segment and to provide much needed calibration algorithms between our existing in vivo MRI biometry and cadaver biometry, since cadaver studies are routinely used in IOL design. Moreover, posterior capsule opacification is a common complication of cataract surgery that decreases visual acuity, has been correlated with IOL tilt and decentration, and is of particular concern with new IOL designs. Soemmering's ring, develops after virtually every IOL implantation, is a direct precursor to PCO, is associated with other complications including pupillary block glaucoma, and our preliminary data suggest that it is also closely associated with IOL malposition. We plan to develop methods of non-invasively grading Soemmering's ring in vitro with MRI and correlating Soemmering's ring in the pseudophakic cadaver globe with anterior segment biometry and IOL type, position, tilt, and decentration. Successful completion of this project will facilitate the construction of models that allow better pseudophakic, phakic, and accommodating IOL designs as well as other methods of presbyopia correction to be simulated and developed. Moreover, it will facilitate the construction of refined algorithms for preoperative IOL power calculations and improve our understanding of post-operative complications of IOL surgery. Cataract surgery is a common procedure that results in removal of the human lens and its replacement with an intraocular lens (IOL). It is a safe procedure, but complications do occur. Many new IOLs are being designed to further improve vision after cataract surgery; however, concerns exist regarding both the safety and effectiveness of these new designs. Magnetic resonance imaging has the unique ability to fully show the IOL position in the intact eye and will be used to study cadaver globes with IOLs in order to better understand the complications that can occur after IOL implantation and also to permit better and safer IOLs to be designed.