Core

核心包括三个部分：临床核心、动物核心和组织学核心。临床核心 提供最先进的带有头皮和蝶骨或脑内电极和视频的有线脑电遥测 监测；完整的外科手术设备，用于外科切除和立体定向放置深度电极 必要时；辅助诊断测试，包括CT、MRI、PET、MEG、fMRI、MRS、数字减影 磁共振血管造影术，专门的神经认知测试，颈动脉内异巴比妥手术， 定量脑电分析；以及一个由神经外科医生、神经学家、临床神经生理学家组成的团队 精神病学家、神经心理学家、神经放射科医生、临床护理专家和遥测技术专家， 所有人都专门研究癫痫，以及提供技术和行政支持的人员。诊断和 手术程序是标准化的，以实现最佳的患者护理，这也促进了临床数据的应用 基础研究项目。动物核负责制备匹罗卡品大鼠和小鼠 所有调查人员都使用的模型，配有视频-EEG设施和人员，以连续监测动物 基础，行为，以检测癫痫的发生，和电生理，以表征 发作间期和发作期癫痫样事件的发生在必要时。组织学的核心是 负责进行常规细胞计数、蒂姆氏染色、免疫细胞化学、神经生物素回收 以及三个子项目中用于实验的人、大鼠和小鼠组织的图像分析。这个 CORE的具体目标是：i)确保所有进入CNP方案的患者都得到最好的治疗 可能的临床护理，以及研究项目不会造成额外的风险、不适或经济负担； 二)确保提供开展CNP研究项目所需的所有临床和动物数据 可供CNP调查人员使用；iii)改进人类颞骨的术前评估和外科治疗 脑叶癫痫，以及具有成本效益的动物模型的使用，以扩大对这一疾病的研究；和 协调三个子项目之间合作开展的临床和动物研究。

The Core consists of three parts: a Clinical Core, an Animal Core, and a Histology Core. The Clinical Core provides state-of-the-art cable EEG telemetry with scalp and sphenoidal or intracerebral electrodes and video monitoring; complete surgical facilities for surgical resection and stereotactic placement of depth electrodes when necessary; ancillary diagnostic testing, including CT, MRI, PET, MEG, fMRI, MRS, digital subtraction magnetic resonance angiography, specialized neurocognitive testing, intracarotid amobarbital procedures, quantitative EEG analysis; and a team of neurosurgeons, neurologists, clinical neurophysiologists, a psychiatrist, a neuropsychologist, a neuroradiologist, clinical nurse-specialists, and telemetry technologists, all specialized in epilepsy, as well as personnel for technical and administrative support. Diagnostic and surgical procedures are standardized for best patient care, which also facilitates application of clinical data to basic research projects. The Animal Core is responsible for preparation of the pilocarpine rat and mouse models used by all investigators, with video-EEG facilities and personnel to monitor animals on a continuous basis, behaviorally to detect seizure occurrence, and electrophysiologically, in order to characterize the development of interictal and ictal epileptiform events when this is necessary. The Histology Core is responsible for carrying out routine cell counts, Timm's stain, immunocytochemistry, neurobiotin recovery and image analysis of human, rat, and mouse tissue used for experiments in the three subprojects. The specific aims of the Core are to: i) assure that all patients entered into the CNP protocols receive the best possible clinical care, and that research projects do not create additional risk, discomfort, or financial burden; ii) ensure that all clinical and animal data necessary for carrying out CNP research projects are made available to CNP investigators; iii) improve presurgical evaluation and surgical treatment of human temporal lobe epilepsy, and the cost-effective use of animal models to expand research on this disorder; and iv) coordinate both clinical and animal research being carried out collaboratively among the three Subprojects.