Interventions for Body Dysmorphic Disorder

描述（由申请人提供）：项目摘要：这是第三次也是最后一次提交的竞争更新申请，用于K24职业中期研究者奖以患者为导向的研究。该奖项将为继续指导初出茅庐的研究人员提供必要的支持，并将大大提高我以病人为导向的研究。我目前的K24奖，在8/06结束，为我的指导提供了关键的支持，使我能够开发新的研究技能。与K24的目的一致，在我目前的奖项，我写了85出版物（81出版或出版，4提交），其中许多是由学员合著。我还获得了额外的联邦资金，为35名学员提供了研究指导，并参加了许多额外的国家和地方指导和领导活动。我是身体畸形障碍（BDD）的极少数研究人员之一，BDD是一种异常严重，相对常见且未得到充分研究的疾病，与自杀意念，自杀企图和自杀完成率显着升高有关。我的主要职业目标是：1）继续以患者为导向的BDD研究（特别是其治疗），2）继续招募和指导以患者为导向的研究中的初级研究人员。我的研究计划包括目前联邦政府资助的BDD干预研究。获奖期间的新研究将主要集中在开发和测试创新的新疗法。这些研究将包括一项比较药物治疗和CBT的疗效研究，以及为自杀倾向更高的患者开发联合治疗。一些研究将包括翻译组件。我的指导计划将主要集中在干预研究以及BDD具体。我在开发和测试药理学和心理社会干预方面积累了专业知识，这在干预者中相对不常见，这增强了我的指导。我将继续指导个别学员，并参加国家和地方的辅导活动。我的指导计划还包括提交T32研究培训补助金申请，用于OCD和BDD的干预和转化（基础临床）研究。这个领域的初级调查人员非常有限。更新我的K24奖将提供必要的支持指导，使我能够维持我的研究成果计划。与公共卫生的相关性：BDD虽然认识不足，但相对普遍。与大多数其他严重精神疾病相比，它与更大的自杀倾向和更差的功能和生活质量有关。继续BDD研究至关重要，通过指导，培养一批研究人员继续这项工作。我对干预研究的指导更广泛地将有助于满足这一至关重要的领域对未来研究人员的迫切需求。

DESCRIPTION (provided by applicant): Project Summary: This is the third and final submission of a Competing Renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research. This award will provide essential support for continued mentoring of beginning investigators and will greatly enhance my patient-oriented research. My current K24 award, which ends in 8/06, has provided critical support for my mentoring and has enabled me to develop new research skills. Consistent with the purpose of the K24, during my current award, I have written 85 publications (81 published or in press, and 4 submitted), many of which were co-authored by mentees. I have also obtained additional federal funding, provided research mentoring to 35 mentees, and participated in many additional national and local mentoring and leadership activities. I am one of the very few researchers of body dysmorphic disorder (BDD), an unusually severe, relatively common, and understudied disorder that is associated with markedly high rates of suicidal ideation, suicide attempts, and completed suicide. My primary career goals are to 1) continue patient- oriented research on BDD (in particular, its treatment), and 2) continue to recruit and mentor beginning researchers in patient-oriented research. My research plan includes current federally funded intervention studies for BDD. New research during the award period will focus primarily on developing and testing innovative new treatments. These studies will include an efficacy study comparing pharmacotherapy and CBT, and development of a combined treatment for more highly suicidal patients. Several studies will include translational components. My mentoring plan will focus primarily on interventions research as well as BDD specifically. I have developed expertise in developing and testing both pharmacologic and psychosocial interventions, which is relatively uncommon among interventionists and which enhances my mentoring. I will continue to mentor individual mentees and participate in national and local mentoring activities. My mentoring plan also includes submitting a T32 research training grant application on interventions and translational (basic-clinical) research on OCD and BDD. This area has a very limited pipeline of beginning investigators. Renewal of my K24 award will provide essential support for mentoring and enable me to sustain my fruitful program of research. Relevance to Public Health: BDD, although underrecognized, is relatively common. It is associated with greater suicidality and poorer functioning and quality of life than most other serious mental illnesses. It is critically important to continue BDD research and, through mentoring, develop a cadre of researchers to continue this work. My mentoring on interventions research more broadly will help meet a pressing need for future researchers in this critically important area.