Dual-Function Reagents in Organic Synthesis

羧基化反应是有机化学中的一个基本反应。我们正在领导一个开发新型羧化反应试剂的项目（最近的出版物见：Angew。2023，DOI：10.1002/anie·202218371）。这些试剂被描述为双功能试剂，因为它们可以在反应中发挥多种作用。我们的双功能试剂的优势在于它们避免了专门的设备和敏感/危险试剂。这些试剂还显示出独特的反应性。该项目将开始与羧化化学的重点，但将提供成功的候选人有机会表达他们的创造力在其他领域的有机合成，例如硫化学和酰胺键的形成。成功的候选人还将获得同位素标记的经验，旨在与学术界和工业界的专家开展合作。成功的候选人将获得合成有机化学，有机金属化学和催化方面的技能。在此范围内，候选人将接触到一系列技术，如光化学和电化学。将使用实验（NMR、CV、UV-Vis、动力学分析）和计算分析技术。将鼓励候选人在国家和国际会议上介绍他们的研究。

Carboxylation is a fundamental reaction in organic chemistry. We are heading a program for developing novel reagents for carboxylation reactions (for a recent publication see: Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202218371). These reagents are described as dual-function reagents as they can perform multiple roles in the reaction. The advantage of our dual-function reagents is that they avoid specialized equipment and sensitive/hazardous reagents. These reagents also display unique reactivity. The project will begin with a focus on carboxylation chemistry but will provide the successful candidate with an opportunity to express their creativity in other areas of organic synthesis, for example sulfur chemistry and amide bond formation. The successful candidate will also gain experience in isotope labeling with an aim to develop collaborations with experts from academia and industry.The successful candidate will acquire skills in synthetic organic chemistry, organometallic chemistry and catalysis. Within this, the candidate will be exposed to a range of technologies, such as photochemistry and electrochemistry. Analytical techniques, both experimental (NMR, CV, UV-Vis, kinetic analysis) and computational will be used. Candidates will be encouraged to present their research at both national and international conferences.