SPORE in Prostate Cancer

描述(由申请者提供)：梅奥诊所综合癌症中心的前列腺癌卓越研究专业计划(SPORT)将支持一个由基础、临床和人口科学研究人员组成的跨学科团队，进行旨在显著降低前列腺癌死亡率的转化性研究。唐纳德·丁德尔博士将担任首席调查员，布莱恩·J·戴维斯博士将担任联合首席调查员。孢子的翻译研究目标将由六个研究项目指导：项目1：血清和组织生物标记物在明确治疗后PSA上升的男性人群中预测对雄激素剥夺治疗的反应(George G.Klee，M.D.，Ph.D.)，项目2：振动声学前列腺成像(Mostafa Fatei，Ph.D.)，项目3：使用放射性碘的前列腺癌基因治疗(John C.Morris，III，M.D.)，项目4：确定安全性的随机第二阶段临床试验，使用或不使用自体骨髓树突状细胞的同种异体全细胞疫苗对雄激素非依赖性前列腺癌患者的耐受性和有效性(StAnimir Vuk-Pavlovic，Ph.D.)，以及项目5：一种基于免疫的前列腺癌治疗方法(Esteban Cells，M.D.，Ph.D.)。五个核心资源将支持这些研究项目：核心1：行政核心(Donald J.Tindall，Ph.D.)，核心2：生物医学核心(John C.Cheville，M.D.)，核心3：临床核心(Brian J.Davis，M.D.，博士)，核心4：生物统计学核心(Eric J.Bergstralh，M.S.)，核心5：患者权益倡导核心(Donald D.Layton，Jr.，M.D.)已经建立了一个发展研究计划，以探索创新研究的机会，并组织了一个职业发展计划，以帮助年轻的研究人员在前列腺癌翻译研究中建立独立性。孢子结构提供了理想的机制来集中和整合研究人员的发现努力，并以最佳方式利用梅奥诊所的临床资源，继续在前列腺癌治疗方面取得有意义的进展。

DESCRIPTION (provided by applicant): This Specialized Program of Research Excellence (SPORE) in prostate cancer at the Mayo Clinic Comprehensive Cancer Center will support an interdisciplinary team of basic, clinical, and population science investigators to perform translational research directed at significantly reducing mortality from this malignancy. Donald J. Tindall, Ph.D., will serve as the Principal Investigator and Brian J. Davis, M.D., Ph.D., will serve as Co-Principal Investigator. The translational research objectives of the SPORE will be directed by six research projects: Project 1: Utility of Serum and Tissue Biomarkers for Predicting Response to Androgen Deprivation Therapy in the Population of Men with Rising PSA Following Definitive Treatment (George G. Klee, M.D., Ph.D.), Project 2: Prostate Imaging by Vibro-acoustography (Mostafa Fatemi, Ph.D.), Project 3: Gene Therapy of Prostate Cancer Using Radioactive Iodine (John C. Morris, III, M.D.), Project 4: A Randomized Phase II Clinical Trial to Determine the Safety, Tolerability and Efficacy of an Allogeneic Whole Cell Vaccine Administered With or Without Autologous Myeloid Dendritic Cells to Patients Suffering From Androgen Independent Prostate Carcinoma (Stanimir Vuk-Pavlovic, Ph.D.), and Project 5: An Immune-Based Therapeutic Approach for Prostate Cancer (Esteban Cells, M.D., Ph.D.). Five core resources will support these research projects: Core 1: Administrative Core (Donald J. Tindall, Ph.D.), Core 2: Biospecimens Core (John C. Cheville, M.D.), Core 3: Clinical Core (Brian J. Davis, M.D., Ph.D.), Core 4: Biostatistics Core (Eric J. Bergstralh, M.S.), and Core 5: Patient Advocate Core (Donald D. Layton, Jr., M.D.) A Developmental Research Program has been established to explore opportunities for innovative research and a Career Development Program has been organized to facilitate young investigators to establish independence in prostate cancer translational research. The SPORE structure provides the ideal mechanism to focus and integrate the discovery efforts of investigators and to optimally utilize the clinical resources of the Mayo Clinic practice to continue to make meaningful advances in the management of prostate cancer.