Osteolysis and Implant Wear: Biological, Biomedical Engineering, and Surgical Pri

描述(申请人提供)：随着我们人口的老龄化和寿命的延长，以及在更年轻、更活跃的患者中进行全关节置换，与假体佩戴相关的翻修手术变得越来越常见。2002年，美国进行了43,000例髋关节翻修术和35,000例膝关节翻修术，其中大部分是由于磨损相关的松动和假体周围的骨溶解。翻修手术在技术上比主要手术更困难，并发症发生率更高，临床结果更难预测，成本也更高。伴随着磨损相关的衰竭而产生的显著的骨丢失，需要广泛的植骨和特殊的假体装置。因此，临床医生应该了解与假体磨损相关的基本原则，以预防、诊断和治疗与假体磨损相关的问题。 美国整形外科医师学会2007年骨溶解和植入磨损：生物、生物医学工程和外科原理(IW)研讨会将有助于确定与植入磨损相关的临床、生物学、工程和材料问题，并研究性别、种族和民族之间的差异。IW研讨会将由斯图尔特·古德曼博士和蒂莫西·赖特博士共同组织，他们曾在1995年和2000年共同主持过关于服装的研讨会。在过去的七年里，已经取得了很大的进展，这使得再次有必要回答与种植体磨损有关的问题。 IW研讨会将于2007年11月9日至11日在德克萨斯州奥斯汀举行，地点在奥斯汀万豪酒店，这是一个完全无障碍的酒店和会议中心。每一次会议将由一名在会议主题方面有专业知识的医生或研究人员主持。教职员工是一个由来自美国和海外的40名男女组成的多元化群体。其他与会者将包括五名青年调查员(YI)、七名工业界代表和四名潜在的政府代表。该项目将使5名住院医生/研究人员有机会与该领域的主要研究人员一起参加IW研讨会。彝族申请者必须在42岁以下或接受培训后不到8年。在过去的研讨会上，彝族申请者代表了广泛的种族和民族多样性，大约30%-40%的彝族申请者是女性。 IW研讨会将面向整形外科医生、生物材料科学家、生物机械工程师和对改善关节置换的长期临床成功感兴趣的生物学家。专题讨论会的成果将通过《美国整形外科学会杂志》(JAAOS)特刊向肌肉骨骼界传播，该杂志将邮寄给16,000名AAOS研究员，并将在JAAOS网站和AAOS矫形外科知识在线上向公众免费提供。

DESCRIPTION (provided by applicant): As our population ages and life spans extend, and as total joint replacement is being performed in younger, more active patients, revision surgeries associated with prosthetic wear are becoming common. In 2002, 43,000 revision hip replacements and 35,000 revision knee replacements were carried out in the USA, the majority being due to wear-associated loosening and periprosthetic osteolysis. Revision procedures are technically more difficult than primary procedures, with a higher complication rate, a less predictable clinical outcome and a higher cost. The significant bone loss that accompanies wear-related failure necessitates extensive bone grafting and special prosthetic devices. Consequently, the clinician should know the basic principles relevant to prosthetic wear to prevent, diagnose, and treat patients with wear-associated problems. The American Academy of Orthopaedic Surgeons' 2007 Osteolysis and Implant Wear: Biological, Biomedical Engineering and Surgical Principles (IW) symposium will serve to identify clinical, biological, engineering and material questions relevant to implant wear and to examine differences among gender, race, and ethnicity. The IW symposium will be co-organized by Stuart Goodman MD, PhD, and Timothy Wright, PhD, who co-chaired prior workshops on wear in 1995 and 2000. Much progress has been made in the past seven years, making it again necessary to answer questions related to implant wear. The IW symposium will be on November 9-11, 2007, in Austin, TX at the Austin Marriott, a fully-accessible hotel and meeting center. Each session will be moderated by a physician or researcher with expertise in the session topic. The faculty are a diverse group of forty women and men from the US and abroad. Other participants will include five Young Investigators (YI), seven representatives from industry, and four potential government representatives. The YI Program will give five residents/researchers the opportunity to attend the IW symposium with principal investigators in the field. YI applicants must be under 42 years of age or less than eight years beyond training. The YI applicants in past symposia have represented a wide spectrum of racial and ethnic diversity, and approximately 30-40% of YI applicants have been female. The IW symposium will serve orthopaedic surgeons, biomaterials scientists, biomechanical engineers, and biologists interested in improving the long-term clinical success of joint replacements. The results of the symposium will be disseminated to the musculoskeletal community through a special issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), which will be mailed to 16,000 AAOS Fellows, and will also be freely available to the public on the JAAOS website and AAOS Orthopaedic Knowledge Online.