NICHD 多中心新生儿合作研究网络-猫眼课题宝

NICHD 多中心新生儿合作研究网络

批准号：

7219993

负责人：

KATHLEEN A KENNEDY

金额：

$49.33万

依托单位：

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-07-17 至 2011-03-31

来源：

https://reporter.nih.gov/project-details/7219993

关键词：

Abdomen Abscess Accident and Emergency department Accounting Achievement Acids Acute Address Administrator Admission activity Adolescence Adrenal Cortex Hormones Adverse effects Advisory Committees Advocate African American Age All Sites American American College of Obstetricians and Gynecologists American Heart Association Amino Acids Aminophylline Ammonia Amniocentesis Amphotericin Ancillary Study Anesthesiology Animal Experimentation Animals Annual Reports Appendix Appointment Area Arts Asians Asphyxia Aspirin Attention Attenuated Attitude Audiology Auditory system Award B lymphocyte immortalization Back Basic Science Beds Benchmarking Bilirubin Biochemistry Bioethics Biology Biometry Birth Birth Weight Blinded Blindness Blood Pressure Board Certification Brain Brain Injuries Breast Feeding Bronchopulmonary Dysplasia Canada Candida Cannulas Cardiac Cardiology Caregivers Caring Carmustine/Cytarabine/Etoposide/Melphalan Case Management Catchment Area Cells Censuses Cerebral Palsy Certification Cesarean section Cessation of life Chairperson Characteristics Charge Child Child Development Childhood Cities Class Classification Clinic Clinic Visits Clinical Clinical Ethics Committees Clinical Investigator Clinical Research Clinical Services Clinical Skills Clinical Trials Clinical Trials Cooperative Group Clinics and Hospitals Cohort Studies Cold Therapy Collaborations Collection Commit Committee Members Communicable Diseases Complement Complex Comprehensive Health Care Computer software Computerized Medical Record Computers Condition Confidence Intervals Conflict (Psychology)Consensus Consent Consent Forms Consult Consultations Continuity of Patient Care Continuous Positive Airway Pressure Contracts Core Facility Counseling Country County County Hospitals Critical Care Critical Illness DNA DNA Sequence Daily Data Data Analyses Data Collection Databases Dedications Defect Deglutition Delivery Rooms Development Developmental Endocrinology Devices Dexamethasone Diabetes Mellitus Diagnosis Diaphragmatic Hernia Dietary Intervention Direct Costs Disadvantaged Discipline Discipline of obstetrics Disease Distant District Hospitals Doctor of Medicine Doctor of Philosophy Dose Double-Blind Method Drainage procedure Dyes Economics Education Educational Curriculum Educational process of instructing Educational workshop Effectiveness Elevator Emergency Situation Emergency treatment Encephalopathies Endocrinology Endocrinology, Other Enrollment Enteral Feeding Environment Environmental air flow Epidemiologic Studies Epidemiologist Epidemiology Equation Equilibrium Equipment Equipment and Supplies Equipoise Ethnic Origin Evaluation Event Evidence Based Medicine Evoked Potentials, Auditory, Brain Stem Excision Exclusion Criteria Expenditure Experimental Designs Extremely Low Birth Weight Infant Facility Construction Funding Category Faculty Family Fellowship Fellowship Program Female Fetal Growth Fetus Financial Support Floor Follow-Up Studies Foundations Friends Funding Funding Agency Fundoplication Future Gastroenterology Gastrostomy Gender Gene Expression Regulation General Anesthesia General Hospitals Generic Drugs Genes Genetic Genetic screening method Genomics Genotype Gestational Age Gifts Glutamine Goals Gold Grant Greater sac of peritoneum Growth Growth Factor Guidelines Gynecology HIV Health Maintenance Organizations Health Policy Health Services Research Health education Healthcare Hearing Helicopter Hematology High-Frequency Ventilation Hispanics Home visitation Hospital Costs Hospital Departments Hospital Medical Staff Hospital Volunteers Hospitals Hour House Call Housing Human Milk Human Resources Humanism Hypertension Hyponatremia Hypotension Hypoxia Ileocecal Valve Image Impairment Income Individual Indomethacin Industry Infant Infant Care Infant Development Infant Health Infection Infertility Inflammatory Response Influentials Information Sciences Information Systems Informed Consent Inositol Inpatients Institutes Institution Insulin Insurance Insurance Coverage Intensive Care Internal Medicine International Intervention Intestinal Perforation Intestines Intravenous Intubation Investigational Drugs Joints Journals Judgment K-Series Research Career Programs Laboratories Laboratory Research Laparotomy Lead Left Length Length of Stay Letters Libraries Life Life Style Ligation Light Link Liposomes Liquid substance Liver Liver Dysfunction Local anesthesia Location Logistic Regressions Long-Term Effects Low Birth Weight Infant Lung Magnetic Resonance Imaging Manuscripts Masks Master of Public Health Master&apos s Degree Maternal and Child Health Measures Mechanical ventilation Meconium Aspiration Medicaid Medical Medical Errors Medical Ethics Medical Indigency Medical Informatics Medical Records Medical Staff Medical center Medicine Meningitis Meningomyelocele Mentored Clinical Oncology Award Mentored Clinical Scientist Award Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Mesoporphyrins Meta-Analysis Methods Mexican Americans Microbiology Minnesota Modification Molecular Molecular Biology Molecular Medicine Monitor Morbidity - disease rate Mosses Mothers Multicenter Studies Multicenter Trials Multiple Pregnancy Mycoses Names National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Drug Abuse Necrotizing Enterocolitis Neonatal Neonatal Brain Injury Neonatal Intensive Care Neonatal Intensive Care Units Neonatology Nephrology Netherlands Neurodevelopmental Impairment Neurologic Neurological outcome Neurological status Neurology New England New Jersey New Zealand Newborn Infant Newborn Respiratory Distress Syndrome Nitric Oxide Nobel Prize Nose Numbers Nurseries Nurses Nursing Research Nursing Services Observational Study Obstetrics Departments Occupational Therapist Odds Ratio Omega-3 Fatty Acids Operating Rooms Operative Surgical Procedures Ophthalmologist Ophthalmology Oral Orthopedics Other Finding Otolaryngology Outcome Outcome Measure Outcomes Research Outpatients Oxidative Stress Oxygen PDC gene Pain Palivizumab Paper Parenteral Nutrition Parents Participant Patent Ductus Arteriosus Pathogenesis Pathologist Pathology Patient Care Patients Pediatric Radiologist Pediatric Research Pediatric Surgical Procedures Pediatrics Peer Review Pelvis Performance Perinatal Perinatal Care Perinatal Epidemiology Perinatal Infection Perinatology Peripheral Peritoneal Persistent Fetal Circulation Syndrome Persons Pharmaceutical Preparations Phototherapy Physician Executives Physicians Physiology Pilot Projects Placebos Plasma Platelet Count measurement Play Pliability Policies Population Positioning Attribute Postdoctoral Fellow Postoperative Period Pregnancy Pregnant Women Premature Infant Premature Labor Prematurity of fetus Preparation Prevention Principal Investigator Private Hospitals Probiotics Procedures Process Productivity Program Development Prophylactic treatment Proteins Protocol Compliance Protocols documentation Psyche structure Psychologist Public Health Public Health Informatics Public Health Nurses Public Health Nursing Public Health Schools Publications Published Comment Publishing Pulmonology Purpose Quality Control Race Radioimmunoassay Radiology Specialty Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Randomized Controlled Trials Range Rate Recommendation Records Registered nurse Registries Relative (related person)Relative Risks Reporting Reproductive Health Research Research Design Research Ethics Committees Research Personnel Research Project Grants Research Training Residencies Resources Respiratory Failure Respiratory Therapy Rest Retinal Diseases Retinopathy of Prematurity Review Committee Review, Systematic (PT)Risk Risk Factors Role Rosa Rotation Running Safety Sample Size Sampling Schedule Scheme Schools Science Score Screening procedure Secure Security Sedation procedure Seizures Senior Scientist Sepsis Series Serum Services Severity of illness Sex Characteristics Shunt Device Side Site Skin Social Security Number Social Work Social Workers Societies Socioeconomic Status Sodium Source Specialist Specific qualifier value Speech Standardization Standards of Weights and Measures Statistically Significant Sterile coverings Sterility Steroids Stomach Stomas Study Section Subgroup Substance abuse problem Supervision Supplementation Support Groups Supraventricular tachycardia Surgeon Surgical sutures Surveys Survival Rate Survivors Syndrome System Tail Taurine Techniques Technology Assessment Telephone Telephone Number Tennessee Teratogens Testing Texas Textbooks Therapeutic Thinking Time Tin Tracheostomy procedure Training Training Programs Transfusion Translations Transportation Treatment Protocols Tube USA Georgia Ultrasonography Uninsured United States Agency for Healthcare Research and Quality United States Food and Drug Administration United States National Institutes of Health Universities Upper arm Urology Vaginal delivery procedure Validation Variant Vasoconstrictor Agents Venous Ventilator Very Low Birth Weight Infant Vision Visit Vital Statistics Vitamin A Wages Washington Water Week Western Asia Georgia Wisconsin Woman Wood material Work Writing base career clinical epidemiology cohort college concept cost cost effectiveness cytokine data management database design day deafness demographics design disability disease mechanisms study early childhood early onset elementary school emotional distress experience feeding fetal fetus surgery follow-up foot gastrointestinal health care economics high school human subject improved inclusion criteria indexing infancy infant outcome inhaled nitric oxide inner city innovation insight instructor interest intervention program lectures male medical schools medical specialties member mortality natural hypothermia neonatal hypoxic-ischemic brain injury neonatal resuscitation neonate neuroimaging neurosurgery news oncology osteopath outcome forecast pathogen patient safety pediatric department pediatrician phosducin phosphoric diester hydrolase pilot trial postnatal preference prenatal prevent professor programs prospective racial and ethnic disparities research facility respiratory role model school health sex simulation size skills sound statistics success sucking surfactant symposium thiazide treatment effect trend trial comparing tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine user-friendly wound

项目摘要

项目成果

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中文摘要

翻译

描述(申请人提供)：概述。德克萨斯大学休斯顿分校是MFM和新生儿研究网络的成员。它为新生儿网络提供了以下内容：1.庞大、高风险且不断增长的人口。2003年，我们的两家医院共有9212例分娩、1181例NICU入院和369例极低出生体重儿，这两家医院总共有136张NICU床位：纪念赫尔曼医院(MHH)和林登·贝恩斯·约翰逊综合医院(LBJ)，前者是一家拥有庞大转诊基础的私立医院，后者是一家以墨西哥裔美国人为主的县医院；2.参加网络研究的总人数很高。我们在16个网络中心中排名第三，在低温和基准试验中排名第二，在光疗和谷氨酰胺试验中排名第二，在Premie吸入性一氧化氮试验中排名第一；3.一个精通临床研究并致力于网络的PI&COPI。PIE是乔恩·泰森，医学博士，公共卫生硕士，临床研究和循证医学中心主任，获得道格拉斯·K·理查森围产期和儿科保健研究奖和临床研究培训项目主任协会颁发的杰出教育者奖。副本是凯瑟琳·肯尼迪，医学博士，公共卫生硕士，围产期流行病学项目和临床研究硕士项目主任。在过去的14年里，他们一直担任私家侦探和副手(在达拉斯有10年，在休斯顿有4年)，以致力于模范研究和帮助其他调查人员而闻名。泰森博士担任维生素A委员会主席(最近发表的后续研究结果)，同时领导同时研究委员会，是自议定书审查委员会成立以来唯一连续担任该委员会成员的非政府组织。他还高度参与了低温试验(见《新英格兰杂志》)；4.在网络研究中担任主要角色的多名有才华的教员。这些人包括a)领导光疗试验的布伦达·莫里斯医学博士(注册现已完成；n=1973名ELBW婴儿)和支持试验的现场主任；b)马丁·布莱克利，医学博士，医学硕士，儿科外科医生和K23接受者，他领导了最近完成的NEC观察性研究(第一篇手稿已发表；第二篇评论中)。与泰森博士一起，他正在提议一项基于结果的重大试验；c)罗伯特·拉斯基，博士，NIH资助的神经心理学家，正在领导光疗试验中听觉脑干诱发反应的一个重要子研究(&gt；50%来自休斯顿大学)；d)Nehal Parikh，Do，K23奖获得者，正在进行的AEEG研究、支持性试验的MRI二次研究和拟议的癫痫预防试验的现场主任；e)MFM网络的Sue Ramin，医学博士，PI，新生儿网络研究的倡导者；和f)拉里·吉尔斯特拉普，医学博士，产科主席，MFM网络公司PI，新生儿网络咨询委员会成员；5.方法学和多学科专业知识。泰森博士领导的中心提供了21名具有生物伦理学、生物统计学、流行病学、卫生保健经济学和卫生服务研究专业知识的教职员工。

英文摘要

DESCRIPTION (provided by applicant): OVERVIEW. UT Houston is a member of both the MFM and Neonatal Research Networks. It provides the following to the Neonatal Network: 1. A large, high-risk, and growing population. In 2003, we had a total of 9212 deliveries, 1181 NICU admissions, & 369 VLBW infants in our 2 hospitals which house 136 total NICU beds: Memorial Hermann Hospital (MHH), a private hospital with a large referral base, and Lyndon Baines Johnson General Hospital, (LBJ), a county hospital serving a largely Mexican American population; 2. High total enrollment in Network studies. We ranked 3rd of 16 Network centers in the Hypothermia & Benchmarking Trials, 2nd in the Phototherapy & Glutamine Trials, and 1st in the Premie Inhaled Nitric Oxide Trial; 3. A PI & CoPI skilled in clinical research & committed to the Network. The PI is Jon Tyson, MD, MPH, Director of the Center for Clinical Research and Evidence Based Medicine & recipient of the Douglas K. Richardson Award for perinatal and pediatric healthcare research and the Distinguished Educator Award from the Association of Clinical Research Training Program Directors. The CoPI is Kathleen Kennedy, MD, MPH, Director of the Perinatal Epidemiology Program and the Master's Degree Program in Clinical Research. They have served as PI and CoPI for the past 14 years (10 in Dallas & 4 in Houston) and are known for their dedication to exemplary research & helping other investigators. Dr. Tyson chaired the Vitamin A Committee (follow-up findings recently published), directs the Concurrent Research Committee, and is the only PI to have served continuously on the Protocol Review Committee since its inception. He has also been highly involved in the Hypothermia Trial (in press, New England Journal); 4. Multiple talented faculty taking major roles in Network research. These include a) Brenda Morris, MD who is directing the Phototherapy Trial (enrollment now completed; n = 1973 ELBW infants) and is site director for the SUPPORT Trial; b) Martin Blakely, MD, MS, a pediatric surgeon & K23 recipient who directed the recently completed the NEC Observational Study (1st manuscript published; 2nd in review). With Dr. Tyson, he is proposing a major trial based on the results; c) Robert Lasky, PhD, an NIH-funded neuropsychologist who is directing an important substudy of auditory brainstem evoked responses in the Phototherapy Trial (>50% of enrollment from UT Houston); d) Nehal Parikh, DO, a K23 award recipient, who is the site director for the ongoing aEEG study, the MRI secondary study of the Support Trial, and the proposed seizure prophylaxis trial; e) Sue Ramin, MD, PI of the MFM Network and advocate for Neonatal Network studies; and f) Larry Gilstrap, MD, Chairman of Obstetrics, Co PI of the MFM Network, and Neonatal Network Advisory Board member; 5. Methodological & multi-disciplinary expertise. The Center that Dr. Tyson directs provides ready access to 21 faculty with expertise in bioethics, biostatistics, epidemiology, health care economics, and health services research.

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