WIHS Data Management and Analysis Center(WDMAC)

妇女机构间艾滋病毒研究(WIItS)是一项大型、全面的队列研究，旨在调查 一系列与妇女艾滋病毒感染的发病机制和自然病史有关的问题 高效抗逆转录病毒治疗的时代。此应用程序的目的是扩展对WIHS的支持 数据管理和分析中心(WDMAC)将继续在以下方面发挥领导作用 流行病学和统计学专业知识为WIHS研究议程提供了稳定和有效的数据 管理系统，并协调研究方案和WIHS调查员倡议，以 提高WIHS数据和科学研究的质量和有效性。的具体目标 WDMAC是：(1)在WIHS研究数据的设计、分析和呈现方面提供领导，并 制定新的统计和流行病学方法，适用于世界卫生组织的科学研究活动 W1HS。这一目标的一个核心组成部分将是区分与正常衰老过程相关的因素 防止艾滋病毒感染和抗病毒疗法的使用；(2)建立、实施和维护数据 一种管理系统，包括数据输入、传输、记录、编辑、存储和 总结。这一目标的组成部分将是建立一个跟踪储存和转移 在国家档案馆保存生物标本，并制作年度公共数据磁带；(3)建立和 实施协调研究活动和科学报告的方法，以促进沟通 在WIHS调查人员、工作组和委员会中，协调研究方案的修订和 表格，并制作全研究范围的队列特征概况(WIHS档案)，研究数据库和 正在进行的研究举措(WDMAC报告)和科学出版物(WIHS档案)；(4) 实施质量保证计划，整合数据管理、研究协调、 统计方法论和科学学科。该计划将促进遵守和培训 标准化的数据收集和管理程序。一项关键的科学倡议将建立在我们的 现有经验，以开发适当的方法来评估治疗的效果 观察性研究。

The Women's Interagency HIV Study (WIItS) is a large, comprehensive cohort study designed to investigate a spectrum of questions relating to the pathogenesis and natural history of HIV infection among women in the era of highly active antiretroviral therapy. The purpose of this application is to extend support of the WIHS Data Management and Analysis Center (WDMAC) which will continue to provide leadership in contributing epidemiological and statistical expertise to the WIHS research agenda, provide a stable and efficient data management system, and provide coordination of study protocols and WIHS investigator initiatives to enhance the quality and validity of the data and the scientific research in the WIHS. The specific aims of WDMAC are: (1) To provide leadership in the design, analysis, and presentation of WIHS study data and to develop novel statistical and epidemiologic methodology applicable to the scientific research initiatives of the W1HS. A core component of this aim will be to distinguish factors associated with the normal aging process from HIV infection and the use of anti-viral therapies; (2) To establish, implement, and maintain a data management system encompassing data entry, transmission, documentation, editing, storage, and summarization. Components of this aim will be to establish a system for tracking the storage and transfer of biological specimens at the national repository, and produce annual public data tapes; (3) To establish and implement methods to coordinate research initiatives and scientific presentations, to facilitate communication among WIHS investigators, Working Groups, and Committees, to orchestrate revisions of study protocols and forms, and to produce study-wide profiles of cohort characteristics (WIHS Dossier), the study database and ongoing research initiatives (WDMAC Report), and scientific publications (WIHS Archives); (4) To implement a quality assurance program that integrates expertise in data management, study coordination, statistical methodology, and scientific disciplines. This program will promote adherence and training for standardized data collection and management programs. A key scientific initiative will build upon our existing cxperience to develop methods for the appropriate evaluation of the effects of therapies in observational studies.